Screening Patients With Sickle Cell Disease for Kidney Damage



Status:Active, not recruiting
Conditions:Anemia
Therapuetic Areas:Hematology
Healthy:No
Age Range:Any
Updated:2/15/2018
Start Date:April 2009
End Date:December 2020

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This study aims to study the temporal course of sickle nephropathy and assess novel
biomarkers that can predict patients prone to nephropathy.

Sickle cell disease causes kidney damage that gets worse with increasing age, leading to
chronic kidney disease and kidney failure in nearly one third of patients with sickle cell
disease. Some patients develop kidney damage at a young age and others show mild kidney
damage at older ages. We do not know the natural progression of kidney damage in sickle cell
disease patients, nor do we know who is more prone to develop severe kidney damage.
Therefore, currently, there are no preventative measures or treatments for sickle cell
related kidney disease. The purpose of this research study is to collect data that will help
in assessing the progression of kidney damage in sickle cell disease, develop novel urine and
blood tests that can predict kidney damage early, and developing treatment ideas for
intervention and prevention of kidney damage that eventually leads to kidney failure.

Inclusion Criteria:

- Sickle cell disease (i.e. Hgb SS, Hgb SC, Sβ-Thalassemia)

- Individuals at baseline/steady state (absence of fever or acute sickle event, defined
as vaso-occlusive pain crises, acute chest syndrome, splenic sequestration, stroke,
priapism) for three weeks.

- Adult Subjects > 18 years of age: ability to consent to donate blood and/or urine for
research purposes only.

- Newborn to < 18 years of age: ability of parent/legal guardian to consent for
peripheral blood and/or urine samples to be obtained for research purposes only.

Exclusion Criteria:

- Hematologic malignancy

- Patients that either do not have the ability to undergo the informed consent process
or whose parent/legal guardian does not have the ability to undergo the informed
consent process
We found this trial at
7
sites
Chicago, Illinois 60612
Principal Investigator: Victor Gordeuk, MD
Phone: 312-413-0242
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700 Childrens Drive
Columbus, Ohio 43205
(616) 722-2000
Principal Investigator: Susan Creary, MD
Nationwide Children's Hospital At Nationwide Children’s, we are creating the future of pediatric health care....
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Akron, Ohio 44308
Principal Investigator: Prasad Bodas, MD
Phone: 330-543-3805
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Atlanta, Georgia 30322
Principal Investigator: Marianne Yee, MD
Phone: 404-785-2025
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9000 Rockville Pike
Bethesda, Maryland 20892
301-496-2563
Principal Investigator: Courtney D. Fitzhugh, M.D
Phone: 800-411-1222
National Institutes of Health Clinical Center The National Institutes of Health (NIH) Clinical Center in...
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Louisville, Kentucky 40202
Principal Investigator: Ashok Raj, MD
Phone: 502-629-7157
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Louisville, KY
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