Establishing a Non-invasive Method to Measure Your Heart's Performance
| Status: | Recruiting |
|---|---|
| Conditions: | Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 90 |
| Updated: | 4/21/2016 |
| Start Date: | August 2014 |
| End Date: | December 2016 |
| Contact: | Marie Csete, MD, PhD |
| Email: | csete@hmri.org |
| Phone: | 626-795-4343 |
Establishing a Non-invasive Method to Measure Heart Performance
The purpose of the study is to evaluate a new way to examine cardiac function, using
software developed at Caltech. The experimental device is software loaded on an iPhone. The
iPhone is used to capture a pulse (waveform) by simply placing the iPhone lightly over the
neck where the carotid pulse can be felt. In this study the information collected from the
iPhone app is compared to cardiac function data obtained from the current gold standard for
measuring cardiac function, cardiac magnetic resonance imaging (MRI). Subjects referred from
cardiologists will also generally have echocardiography information available for comparison
with the iPhone app. For the study, subjects will have completely non-invasive studies done
in one setting: The iPhone app to capture the waveforms (over carotid and radial (wrist)
arteries), tonometry (another non-invasive method using a modified stethoscope), standard
pulse oximetry, followed by a 30 minute MRI examination of the heart. A second complete
study will be done about 6 months after the first. The complete study session takes about
1.5 hours.
software developed at Caltech. The experimental device is software loaded on an iPhone. The
iPhone is used to capture a pulse (waveform) by simply placing the iPhone lightly over the
neck where the carotid pulse can be felt. In this study the information collected from the
iPhone app is compared to cardiac function data obtained from the current gold standard for
measuring cardiac function, cardiac magnetic resonance imaging (MRI). Subjects referred from
cardiologists will also generally have echocardiography information available for comparison
with the iPhone app. For the study, subjects will have completely non-invasive studies done
in one setting: The iPhone app to capture the waveforms (over carotid and radial (wrist)
arteries), tonometry (another non-invasive method using a modified stethoscope), standard
pulse oximetry, followed by a 30 minute MRI examination of the heart. A second complete
study will be done about 6 months after the first. The complete study session takes about
1.5 hours.
Investigators at Caltech have developed an iPhone-based application that allows them to
capture an arterial waveform using the iPhone camera held over the skin. Then based on the
captured waveform and previous laboratory experiments and models, the investigators are able
to calculate ejection fraction, the percentage of blood that goes out of the heart into the
circulation with each beat. Previous studies suggested that the iPhone app measurements of
ejection fraction were similar to those obtained with traditional cardiac echocardiography.
In the current study the iPhone app measures are being compared to ejection fraction
obtained using cardiac MRI. The iPhone also measures other physical properties of the heart
and aorta that the investigators call "intrinsic frequencies". Using healthy subjects they
have established the normal pattern/range of intrinsic frequencies, and in this study, a
more diverse population of subjects (some with heart disease) will be studied, to determine
how intrinsic frequency measures compare to traditional clinical measures of cardiac
function.
capture an arterial waveform using the iPhone camera held over the skin. Then based on the
captured waveform and previous laboratory experiments and models, the investigators are able
to calculate ejection fraction, the percentage of blood that goes out of the heart into the
circulation with each beat. Previous studies suggested that the iPhone app measurements of
ejection fraction were similar to those obtained with traditional cardiac echocardiography.
In the current study the iPhone app measures are being compared to ejection fraction
obtained using cardiac MRI. The iPhone also measures other physical properties of the heart
and aorta that the investigators call "intrinsic frequencies". Using healthy subjects they
have established the normal pattern/range of intrinsic frequencies, and in this study, a
more diverse population of subjects (some with heart disease) will be studied, to determine
how intrinsic frequency measures compare to traditional clinical measures of cardiac
function.
Inclusion Criteria:
- Adult age 18-90, outpatients
Exclusion Criteria:
- Inability to lie flat for 30 minutes with periodic breath holding
- Metal implants or other standard contraindications to MRI
- Acute cardiac decompensation (active chest pain, shortness of breath)
- Hypotension (SBP<90 mm Hg)
- Claustrophobia
- Patient too large to fit in closed MRI
We found this trial at
1
site
Pasadena, California 91105
Phone: 626-397-5840
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