Compensatory Cognitive Training in Clinical High Risk Latino Youth

This is a 12 week randomized study to compare Compensatory Cognitive Training (CCT) versus
Recreational Therapy (RT) in Latino clinical high risk individuals in the US and Mexico.

Study participants will be measured 3 times, at baseline, 12 and 24 weeks on all outcome
measures. Study hypothesis: Study participants receiving CCT will show significant
improvement at 12 and 24 weeks compared to baseline in 1) Neurocognition using the Global
Cognitive Index z score derived from the MATRICS neurocognitive domain scores, 2) Functional
Capacity as assessed by the UCSD Performance-based Skills Assessment (UPSA/UPSA-Adolescent),
3) Self-Rated Functioning as measured by the Specific Level of Functioning Scale (SLoF) and
4) Clinical symptom ratings as measured by the Scale of Prodromal Symptoms (SOPS) total
score when compared to subjects receiving RT training across study time.

Inclusion Criteria:

- Meet Clinical High Risk criteria

- Be of Latino descent

- Speak Spanish as their preferred language

Exclusion Criteria:

- Concomitant medical or neurological illness

- Brain injury with loss of consciousness > 30 minutes

- Current substance abuse (excluding nicotine)

- IQ < 80

- High suicidal risk