Effect of Oasis® Wound Matrix on Stage III and IV Trunk Pressure Wounds Treated With Negative Pressure Wound Therapy

In this study, patients being treated with Negative Pressure Wound Therapy (NPWT) will be
randomized to receive either:

1. Oasis® matrix, applied to the wound, along with standard of care including NPWT OR

2. Standard foam, applied to the wound prior to activation of NPWT, which is standard care.

Wounds will be examined weekly for up to 12 weeks. At weeks 4, 8, and 12, the NPWT evacuation
canister will be collected for specimen analysis.

The aim of this study is to determine the therapeutic effect of using Oasis® Wound Matrix
with NPWT. Outcomes include: a) closure rate of non-healing wounds, and b) levels of growth
factors and interleukins in fluid evacuated from the wound.

Inclusion Criteria:

- Adults aged 18-89 who exhibit stage III or IV trunk pressure wounds with no signs of
infection.

- HbA1C < 8 (if patient is diabetic)

- Adequate nutrition including albumin above 2.0 and prealbumin above 15.

Exclusion Criteria:

- Wounds that cannot have a NPWT device properly applied due to location (too close to
anus), diarrhea, periwound skin issues.

- Patients with Infected wounds.