A Study Investigating the Efficacy and Safety of Lampalizumab Intravitreal Injections in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration



Status:Completed
Conditions:Ocular
Therapuetic Areas:Ophthalmology
Healthy:No
Age Range:50 - Any
Updated:10/25/2018
Start Date:September 18, 2014
End Date:January 29, 2018

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A Phase III, Multicenter, Randomized, Double-Masked, Sham-Controlled Study to Assess the Efficacy and Safety of Lampalizumab Administered Intravitreally to Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration

This study is a Phase III, double-masked, multicenter, randomized, sham injection-controlled
study evaluating the efficacy and safety of lampalizumab administered by intravitreal
injections in participants with geographic atrophy (GA) secondary to age-related macular
degeneration (AMD).


Inclusion Criteria:

- Well demarcated area(s) of GA secondary to AMD with no evidence of prior or active
choroidal neovascularization (CNV) in both eyes

Exclusion Criteria:

Ocular Exclusion Criteria: Study Eye

- History of vitrectomy surgery, submacular surgery, or other surgical intervention for
AMD

- Previous laser photocoagulation for CNV, diabetic macular edema, retinal vein
occlusion, and proliferative diabetic retinopathy

- Previous intravitreal drug delivery (intravitreal corticosteroid injection,
anti-angiogenic drugs, anti-complement agents, or device implantation) Ocular
Exclusion Criteria: Both Eyes

- GA in either eye due to causes other than AMD

- Previous treatment with eculizumab, lampalizumab and/or fenretinide
We found this trial at
77
sites
Morgantown, West Virginia 26506
164
mi
from 43215
Morgantown, WV
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98-1079 Moanalua Road
'Aiea, Hawaii 96701
4502
mi
from 43215
'Aiea, HI
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5441 Health Center Drive
Abilene, Texas 79606
1068
mi
from 43215
Abilene, TX
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Arlington, Texas 76012
928
mi
from 43215
Arlington, TX
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21 Medical Park Drive
Asheville, North Carolina 28803
305
mi
from 43215
Asheville, NC
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Augusta, Georgia 30909
451
mi
from 43215
Augusta, GA
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Austin, Texas 78705
1064
mi
from 43215
Austin, TX
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Austin, Texas 78705
1064
mi
from 43215
Austin, TX
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Bakersfield, California 93309
1983
mi
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Bakersfield, CA
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3401 Enterprise Place
Beachwood, Ohio 44122
131
mi
from 43215
Beachwood, OH
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Beverly Hills, California 90211
1979
mi
from 43215
Beverly Hills, CA
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1720 7th Avenue South
Birmingham, Alabama 35233
492
mi
from 43215
Birmingham, AL
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Bloomfield, New Jersey 07003
468
mi
from 43215
Bloomfield, NJ
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800 Washington Street
Boston, Massachusetts 02111
642
mi
from 43215
Boston, MA
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Boston, Massachusetts 02114
643
mi
from 43215
Boston, MA
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1717 Woolbright Road
Boynton Beach, Florida 33426
944
mi
from 43215
Boynton Beach, FL
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725 Uruguay
Buenos Aires, C1015ABO
5385
mi
from 43215
Buenos Aires,
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274
mi
from 43215
Chicago, IL
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129
mi
from 43215
Cleveland, OH
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5323 Harry Hines Boulevard
Dallas, Texas 75390
911
mi
from 43215
Dallas, TX
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455
mi
from 43215
Edison, NJ
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Fort Myers, Florida 33912
932
mi
from 43215
Fort Myers, FL
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Grand Rapids, Michigan 49525
247
mi
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Grand Rapids, MI
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200 Motor Parkway
Hauppauge, New York 11788
517
mi
from 43215
Hauppauge, NY
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10300 North Illinois Street
Indianapolis, Indiana 46290
166
mi
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Indianapolis, IN
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1961
mi
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Irvine, CA
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1116 West Ganson Street
Jackson, Michigan 49202
174
mi
from 43215
Jackson, MI
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9551 U.S. 78
Ladson, South Carolina 29456
508
mi
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Ladson, SC
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Las Vegas, Nevada
1756
mi
from 43215
Las Vegas, NV
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4 Princess Road
Lawrenceville, New Jersey 08648
439
mi
from 43215
Lawrenceville, NJ
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16 Hayden Avenue
Lexington, Kentucky 02421
635
mi
from 43215
Lexington, KY
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Lexington, Kentucky 40509
154
mi
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Lexington, KY
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Lincoln, Nebraska 38506
721
mi
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Lincoln, NE
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Los Angeles, California
1972
mi
from 43215
Los Angeles, CA
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360 Merrick Road
Lynbrook, New York 11563
494
mi
from 43215
Lynbrook, NY
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Madison, Wisconsin 53792
(608) 263-2400
University of Wisconsin In achievement and prestige, the University of Wisconsin–Madison has long been recognized...
394
mi
from 43215
Madison, WI
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Marietta, Georgia 30060
423
mi
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Marietta, GA
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McAllen, Texas 78503
1291
mi
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McAllen, TX
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502 East New Haven Avenue
Melbourne, Florida 32901
832
mi
from 43215
Melbourne, FL
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Monroeville, Pennsylvania 15146
173
mi
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Monroeville, PA
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Nashville, Tennessee 37203
333
mi
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Nashville, TN
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Nashville, Tennessee 37212
335
mi
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Nashville, TN
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New York, New York
477
mi
from 43215
New York, NY
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271
mi
from 43215
Oak Forest, IL
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Oakland, California 94609
2098
mi
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Oakland, CA
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Orchard Park, New York 14127
294
mi
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Orchard Park, NY
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Palm Beach Gardens, Florida 33410
920
mi
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Palm Beach Gardens, FL
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Palm Beach Gardens, Florida 33418
922
mi
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Palm Beach Gardens, FL
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36949 Cook Street
Palm Desert, California 92211
1879
mi
from 43215
Palm Desert, CA
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Pensacola, Florida 32503
700
mi
from 43215
Pensacola, FL
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Phoenix, Arizona 85014
1660
mi
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Phoenix, AZ
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Plantation, Florida 33324
969
mi
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Plantation, FL
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Portland, Maine
704
mi
from 43215
Portland, ME
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8411 North Run Medical Drive
Richmond, Virginia 23226
343
mi
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Richmond, VA
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Richmond, Virginia
338
mi
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Richmond, VA
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Royal Oak, Michigan 48073
176
mi
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Royal Oak, MI
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4344 Central Avenue North
Saint Petersburg, Florida 33711
842
mi
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Saint Petersburg, FL
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Salt Lake City, Utah
1513
mi
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Salt Lake City, UT
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1445 Bush Street
San Francisco, California 94107
2107
mi
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San Francisco, CA
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400 Parnassus Avenue
San Francisco, California 94143
2109
mi
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San Francisco, CA
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Santa Ana, California 92705
1960
mi
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Santa Ana, CA
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Santa Barbara, California 93103
2038
mi
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Santa Barbara, CA
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Shawnee Mission, Kansas 66204
624
mi
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Shawnee Mission, KS
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9800 Levin Road Northwest
Silverdale, Washington 98383
2023
mi
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Silverdale, WA
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Southfield, Michigan 48034
173
mi
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Southfield, MI
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Spokane, Washington 99204
1778
mi
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Spokane, WA
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3107 East Genesee Street
Syracuse, New York 13224
416
mi
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Syracuse, NY
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2439 Care Drive
Tallahassee, Florida 32308
659
mi
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Tallahassee, FL
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Tampa, Florida 33609
831
mi
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Tampa, FL
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Towson, Maryland 21204
343
mi
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Towson, MD
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Tucson, Arizona 85704
1641
mi
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Tucson, AZ
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Warrenton, Virginia 20186
292
mi
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Warrenton, VA
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West Des Moines, Iowa 50266
572
mi
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West Des Moines, IA
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West Mifflin, Pennsylvania 15122
165
mi
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West Mifflin, PA
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Willow Park, Texas 76087
999
mi
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Willow Park, TX
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1 Medical Center Blvd
Winston-Salem, North Carolina 27157
306
mi
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Winston-Salem, NC
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Worcester, Massachusetts 01605
604
mi
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Worcester, MA
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