A Study Investigating the Efficacy and Safety of Lampalizumab Intravitreal Injections in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration



Status:Completed
Conditions:Ocular
Therapuetic Areas:Ophthalmology
Healthy:No
Age Range:50 - Any
Updated:10/25/2018
Start Date:September 18, 2014
End Date:January 29, 2018

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Trial Summary
Trial Overview
Inclusion Criteria

A Phase III, Multicenter, Randomized, Double-Masked, Sham-Controlled Study to Assess the Efficacy and Safety of Lampalizumab Administered Intravitreally to Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration

This study is a Phase III, double-masked, multicenter, randomized, sham injection-controlled
study evaluating the efficacy and safety of lampalizumab administered by intravitreal
injections in participants with geographic atrophy (GA) secondary to age-related macular
degeneration (AMD).


Inclusion Criteria:

- Well demarcated area(s) of GA secondary to AMD with no evidence of prior or active
choroidal neovascularization (CNV) in both eyes

Exclusion Criteria:

Ocular Exclusion Criteria: Study Eye

- History of vitrectomy surgery, submacular surgery, or other surgical intervention for
AMD

- Previous laser photocoagulation for CNV, diabetic macular edema, retinal vein
occlusion, and proliferative diabetic retinopathy

- Previous intravitreal drug delivery (intravitreal corticosteroid injection,
anti-angiogenic drugs, anti-complement agents, or device implantation) Ocular
Exclusion Criteria: Both Eyes

- GA in either eye due to causes other than AMD

- Previous treatment with eculizumab, lampalizumab and/or fenretinide
We found this trial at
77
sites
Wake Forest Baptist Health Eye Centre
1 Medical Center Blvd
Winston-Salem, North Carolina 27157
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Winston-Salem, NC
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Retina Consultants of Hawaii
98-1079 Moanalua Road
'Aiea, Hawaii 96701
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'Aiea, HI
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Retina Res Institute of Texas
5441 Health Center Drive
Abilene, Texas 79606
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Abilene, TX
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Texas Retina Associates
Arlington, Texas 76012
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Arlington, TX
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West Carolina Retinal AssocPA
21 Medical Park Drive
Asheville, North Carolina 28803
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Asheville, NC
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Southeast Retina Center, P.C.
Augusta, Georgia 30909
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Augusta, GA
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Austin Retina Associates
Austin, Texas 78705
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Austin, TX
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Retina Research Center
Austin, Texas 78705
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Austin, TX
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California Retina Consultants
Bakersfield, California 93309
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Bakersfield, CA
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Retina Assoc of Cleveland Inc
3401 Enterprise Place
Beachwood, Ohio 44122
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Beachwood, OH
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Retina-Vitreous Associates Medical Group
Beverly Hills, California 90211
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Beverly Hills, CA
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Uni of Alabama At Birmingham Clinical Research Unit
1720 7th Avenue South
Birmingham, Alabama 35233
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Birmingham, AL
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Retina Center of New Jersey, LLC
Bloomfield, New Jersey 07003
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Bloomfield, NJ
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Tufts Medical Center Research
800 Washington Street
Boston, Massachusetts 02111
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Boston, MA
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Ophthalmic Consultants of Boston
Boston, Massachusetts 02114
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Boston, MA
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Florida Eye Microsurgical Inst
1717 Woolbright Road
Boynton Beach, Florida 33426
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Boynton Beach, FL
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Organizacion Medica de Investigacion
725 Uruguay
Buenos Aires, C1015ABO
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Buenos Aires,
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Northwestern Medical Group/Northwestern University
Chicago, Illinois 60611
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Chicago, IL
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Cleveland Clinic Foundation; Cole Eye Institute
Cleveland, Ohio 44195
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Cleveland, OH
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UT Southwestern MC at Dallas
5323 Harry Hines Boulevard
Dallas, Texas 75390
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Dallas, TX
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New Jersey Retina Research Foundation
Edison, New Jersey
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Edison, NJ
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National Ophthalmic Research Institute
Fort Myers, Florida 33912
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Fort Myers, FL
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Vitreo-Retinal Associates
Grand Rapids, Michigan 49525
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Grand Rapids, MI
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Long Is. Vitreoretinal Consult
200 Motor Parkway
Hauppauge, New York 11788
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Hauppauge, NY
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Midwest Eye Institute Northside
10300 North Illinois Street
Indianapolis, Indiana 46290
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Indianapolis, IN
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The Gavin Herbert Eye Institute/UC Irvine
Irvine, California 92697
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Irvine, CA
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Specialty Eye Institute
1116 West Ganson Street
Jackson, Michigan 49202
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Jackson, MI
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Charleston Neuroscience Inst
9551 U.S. 78
Ladson, South Carolina 29456
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Ladson, SC
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Retina Consultants of Nevada
Las Vegas, Nevada
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Las Vegas, NV
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Delaware Valley Retina Assoc
4 Princess Road
Lawrenceville, New Jersey 08648
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Lawrenceville, NJ
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Lahey Clinic Med Ctr
16 Hayden Avenue
Lexington, Kentucky 02421
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Lexington, KY
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Retina Associates of Kentucky
Lexington, Kentucky 40509
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Lexington, KY
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Eye Surgical Associates
Lincoln, Nebraska 38506
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Lincoln, NE
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Jules Stein Eye Institute, UCLA
Los Angeles, California
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Los Angeles, CA
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Opthalmic Consultants of LI
360 Merrick Road
Lynbrook, New York 11563
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Lynbrook, NY
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University of Wisconsin
Madison, Wisconsin 53792
(608) 263-2400
University of Wisconsin In achievement and prestige, the University of Wisconsin–Madison has long been recognized...
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Madison, WI
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Georgia Retina, P.C.
Marietta, Georgia 30060
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Marietta, GA
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Valley Retina Institute, P.A.
McAllen, Texas 78503
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McAllen, TX
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Florida Eye Associates
502 East New Haven Avenue
Melbourne, Florida 32901
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Melbourne, FL
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Retina Vitreous Consultants
Monroeville, Pennsylvania 15146
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Monroeville, PA
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West Virginia University Eye Institute
Morgantown, West Virginia 26506
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Morgantown, WV
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Tennessee Retina, P.C.
Nashville, Tennessee 37203
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Nashville, TN
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Vanderbilt
Nashville, Tennessee 37212
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Nashville, TN
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New York Eye & Ear Infirmary
New York, New York
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New York, NY
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University Retina and Macula Associates, P.C.
Oak Forest, Illinois 60452
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Oak Forest, IL
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East Bay Retina Consultants, Inc.
Oakland, California 94609
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Oakland, CA
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Retina Consultants of Western New York
Orchard Park, New York 14127
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Orchard Park, NY
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Retina Care Specialists
Palm Beach Gardens, Florida 33410
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Palm Beach Gardens, FL
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Bascom Palmer Eye Institute
Palm Beach Gardens, Florida 33418
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Palm Beach Gardens, FL
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Southern CA Desert Retina Cons
36949 Cook Street
Palm Desert, California 92211
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Palm Desert, CA
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Retina Specialty Institute
Pensacola, Florida 32503
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Pensacola, FL
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Retinal Research Institute LLC
Phoenix, Arizona 85014
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Phoenix, AZ
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Fort Lauderdale Eye Institute
Plantation, Florida 33324
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Plantation, FL
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Maine Eye Center
Portland, Maine
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Portland, ME
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Eye Surgeons of Richmond Inc. dba Virginia Eye Institute
8411 North Run Medical Drive
Richmond, Virginia 23226
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Richmond, VA
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Retina Institute of Virginia
Richmond, Virginia
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Richmond, VA
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Assoc Retinal Consultants PC
Royal Oak, Michigan 48073
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Royal Oak, MI
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Retina Vitreous Assoc of FL
4344 Central Avenue North
Saint Petersburg, Florida 33711
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Saint Petersburg, FL
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Retina Associates of Utah
Salt Lake City, Utah
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Salt Lake City, UT
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W Coast Retina Med Group Inc
1445 Bush Street
San Francisco, California 94107
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San Francisco, CA
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UCSF; Ophthalmology
400 Parnassus Avenue
San Francisco, California 94143
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San Francisco, CA
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Orange County Retina Medical Group
Santa Ana, California 92705
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Santa Ana, CA
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California Retina Consultants
Santa Barbara, California 93103
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Santa Barbara, CA
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Retina Associates, PA
Shawnee Mission, Kansas 66204
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Shawnee Mission, KS
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Retina Center Northwest
9800 Levin Road Northwest
Silverdale, Washington 98383
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Silverdale, WA
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Retina Consultants of Michigan
Southfield, Michigan 48034
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Southfield, MI
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Spokane Eye Clinical Research
Spokane, Washington 99204
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Spokane, WA
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Retina Vit Surgeons/Central NY
3107 East Genesee Street
Syracuse, New York 13224
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Syracuse, NY
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Southern Vitreoretinal Assoc
2439 Care Drive
Tallahassee, Florida 32308
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Tallahassee, FL
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Retina Associates of Florida, P.A.
Tampa, Florida 33609
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Tampa, FL
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Retina Specialists
Towson, Maryland 21204
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Towson, MD
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Retina Centers, P.C.
Tucson, Arizona 85704
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Tucson, AZ
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Virginia Retina Center
Warrenton, Virginia 20186
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Warrenton, VA
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Wolfe Eye Clinic
West Des Moines, Iowa 50266
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West Des Moines, IA
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Associates in Ophthalmology
West Mifflin, Pennsylvania 15122
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West Mifflin, PA
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Strategic Clinical Research Group, LLC
Willow Park, Texas 76087
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Willow Park, TX
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Vitreo-Retinal Associates, PC
Worcester, Massachusetts 01605
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Worcester, MA
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