A Study Investigating the Safety and Efficacy of Lampalizumab Intravitreal Injections in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration



Status:Terminated
Conditions:Ocular
Therapuetic Areas:Ophthalmology
Healthy:No
Age Range:50 - Any
Updated:3/16/2019
Start Date:October 6, 2014
End Date:January 23, 2018

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Trial Summary
Trial Overview
Inclusion Criteria

A Phase III, Multicenter, Randomized, Double-Masked, Sham-Controlled Study to Assess the Efficacy and Safety of Lampalizumab Administered Intravitreally to Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration

This study is a Phase III, double-masked, multicenter, randomized, sham injection-controlled
study evaluating the efficacy and safety of lampalizumab administered by intravitreal
injections in participants with geographic atrophy (GA) secondary to age-related macular
degeneration (AMD).


Inclusion Criteria:

- Participants aged greater than or equal to (>/=) 50 years

- Well demarcated area(s) of Geographic Atrophy (GA) secondary to Age-Related Macular
Degeneration (AMD) with no evidence of prior or active choroidal neovascularization
(CNV) in both eyes

Exclusion Criteria:

Ocular Exclusion Criteria (Study Eye):

- History of vitrectomy surgery, submacular surgery, or other surgical intervention for
AMD

- Previous laser photocoagulation for CNV, diabetic macular edema, retinal vein
occlusion, and proliferative diabetic retinopathy

- Previous intravitreal drug delivery (e.g., intravitreal corticosteroid injection,
anti-angiogenic drugs, anti-complement agents, or device implantation)

Ocular Exclusion Criteria (Both Eyes):

- GA in either eye due to causes other than AMD

- Previous treatment with eculizumab, lampalizumab, and/or fenretinide
We found this trial at
68
sites
Retina Group of Florida
Fort Lauderdale, Florida 33334
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Emory University
201 Dowman Dr
Atlanta, Georgia 30303
(404) 727-6123
Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
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University of South Florida
4202 E Fowler Ave
Tampa, Florida 33620
(813) 974-2011
University of South Florida The University of South Florida is a high-impact, global research university...
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Tampa, FL
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Retina Res Institute of Texas
5441 Health Center Drive
Abilene, Texas 79606
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Abilene, TX
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University of Michigan/Kellogg Eye Center
Ann Arbor, Michigan 48105
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Ann Arbor, MI
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West Carolina Retinal AssocPA
21 Medical Park Drive
Asheville, North Carolina 28803
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Asheville, NC
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Retina and Vitreous Center of Southern Oregon, PC
Ashland, Oregon 97520
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Ashland, OR
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University of Colorado
Aurora, Colorado 80045
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Aurora, CO
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The Retina Care Center
Baltimore, Maryland 21209
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Baltimore, MD
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Wilmer Eye Institute
Baltimore, Maryland
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Baltimore, MD
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Vitreoretinal Associates of Washington
Bellevue, Washington 98004
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Bellevue, WA
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Mass Eye and Ear Infirmary
243 Charles Street
Boston, Massachusetts 02114
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Boston, MA
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Oftalmos
1832 Avenida Córdoba
Capital Federal, C1120AAN
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Capital Federal,
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MUSC Storm eye institute
735 Johnnie Dodds Boulevard
Charleston, South Carolina 29464
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Charleston, SC
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Char Eye Ear &Throat Assoc
6035 Fairview Road
Charlotte, North Carolina 28210
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Charlotte, NC
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Univ of Virginia Ophthalmology
1300 Jefferson Park Avenue
Charlottesville, Virginia 22903
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Charlottesville, VA
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Southeastern Retina Associates Chattanooga
1606 Gunbarrel Road
Chattanooga, Tennessee 37421
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Chattanooga, TN
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Mid Atlantic Retina - Wills Eye Hospital
8 Ranoldo Terrace
Cherry Hill, New Jersey 08034
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Cherry Hill, NJ
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Midwest Vision Research Foundation
1815 Clarkson Road
Chesterfield, Missouri 63017
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Chesterfield, MO
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Retina Group of Washington
Chevy Chase, Maryland 20815
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Chevy Chase, MD
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Cincinnati Eye Institute
Cincinnati, Ohio 45242
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Cincinnati, OH
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Retina Consultants of Southern
2770 North Union Boulevard
Colorado Springs, Colorado 80909
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Colorado Springs, CO
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OSU Eye Physicians and Surgeons, LLC.
Columbus, Ohio 43212
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Columbus, OH
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Texas Retina Associates
Dallas, Texas 75231
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Dallas, TX
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Kresge Eye Institute
Detroit, Michigan 48201
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Detroit, MI
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Duke University Eye Center; Vitreoretinal
2351 Erwin Road
Durham, North Carolina 27710
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Durham, NC
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Vitreoretinal Surgery
7760 France Avenue South
Edina, Minnesota 55435
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Edina, MN
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Palmetto Retina Center, LLC
Florence, South Carolina 29501
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Florence, SC
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Retina Health Center
Fort Myers, Florida 33907
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Fort Myers, FL
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Retina Consultants of Orange County
Fullerton, California 92835
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Fullerton, CA
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Charles Retina Institution
1432 Kimbrough Road
Germantown, Tennessee 38138
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Germantown, TN
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Colorado Retina Associates
Golden, Colorado 80401
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Golden, CO
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New England Retina Associates
Hamden, Connecticut 06518
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Hamden, CT
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Retina Consultants of Houston
Houston, Texas 77030
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Houston, TX
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UCSD Shiley Eye Center
La Jolla, California 92093
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La Jolla, CA
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Charleston Neuroscience Inst
9551 U.S. 78
Ladson, South Carolina 29456
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Ladson, SC
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Jules Stein Eye Institute, UCLA
Los Angeles, California
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Los Angeles, CA
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N CA Retina Vitreous Assoc
2485 Hospital Drive
Mountain View, California 94040
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Mountain View, CA
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Bascom Palmer Eye Institute
3880 Tamiami Trail North
Naples, Florida 34103
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Naples, FL
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New York Weil Cornell Med Ctr
New York, New York 10021
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New York, NY
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Vitreous-Retina-Macula
460 Park Avenue
New York, New York 10022
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New York, NY
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Retinal & Ophthalmic Cons PC
1500 Tilton Road
Northfield, New Jersey 08225
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Northfield, NJ
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UNMC Truhlsen Eye Institute
Omaha, Nebraska 68105
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Omaha, NE
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Paducah Retinal Center
Paducah, Kentucky 42001
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Paducah, KY
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Byers Eye Insitute at Stanford
2452 Watson Court
Palo Alto, California 94303
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Palo Alto, CA
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Mid-Atlantic Retina
Philadelphia, Pennsylvania 19107
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Philadelphia, PA
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Associated Retina Consultants
Phoenix, Arizona 85020
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Phoenix, AZ
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Allegheny Ophthalmic & Orbital
420 East North Avenue
Pittsburgh, Pennsylvania 15212
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Pittsburgh, PA
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Retina Northwest, PC
Portland, Oregon 97210
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Portland, OR
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Oregon HSU; Casey Eye Institute
3303 Southwest Bond Avenue
Portland, Oregon 97239
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Portland, OR
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Retina Consultants, San Diego
Poway, California 92064
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Poway, CA
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Black Hills Eye Institute
Rapid City, South Dakota 57701
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Rapid City, SD
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Sierra Eye Associates
Reno, Nevada 89502
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Reno, NV
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Retina Assoc of Western NY
160 Sawgrass Drive
Rochester, New York 14620
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Rochester, NY
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University of California Davis Eye Center
Sacramento, California 95817
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Sacramento, CA
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Retinal Consultants Medical Group, Inc.
Sacramento, California 95819
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Sacramento, CA
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Retina Vitreous Assoc of FL
4344 Central Avenue North
Saint Petersburg, Florida 33711
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Saint Petersburg, FL
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California Retina Consultants
Santa Barbara, California 93103
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Santa Barbara, CA
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Southern Vitreoretinal Assoc
2439 Care Drive
Tallahassee, Florida 32308
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Tallahassee, FL
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Retina Associates of NJ
628 Cedar Lane
Teaneck, New Jersey 07666
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Teaneck, NJ
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Scott & White Hospital
Temple, Texas 76508
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Temple, TX
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Retina Consultants of Houston
The Woodlands, Texas 77384
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The Woodlands, TX
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Retina Specialists
Towson, Maryland 21204
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Towson, MD
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Retina Associates Southwest, PC
Tucson, Arizona 85724
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Tucson, AZ
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Bay Area Retina Associates
Walnut Creek, California 94598
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Walnut Creek, CA
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Retina Group of New England
Waterford, Connecticut 06385
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Waterford, CT
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Wolfe Eye Clinic
West Des Moines, Iowa 50266
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West Des Moines, IA
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Vitreo Retinal Consultants
Wichita, Kansas 67214
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Wichita, KS
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