Development of a Patient-Reported Outcome Measure to Assess Symptoms in Patients With Primary Sclerosing Cholangitis (PSC)

In Step I, concept elicitation one-on-one interviews (via telephone or in person) will be
conducted. The aims of the concept elicitation interviews are to:

1. Identify the most common symptoms, as well as the most important symptoms, for patients
with PSC, and

2. Assess whether these symptoms impact day-to-day functioning

An instrument will be developed based on the symptoms reported and in Step II of the study,
the performance of the instrument will be assessed with further interviews.

Inclusion Criteria:

- Confirmed diagnosis of PSC based on liver biopsy or diagnostic imaging, with
diagnosis made at least three months prior to screening

- Patient report of PSC symptoms associated with PSC diagnosis

- Able to speak, read, and understand English

- Willing and able to provide written informed consent to participate in the research
study

Exclusion Criteria:

- Patients with other causes of liver or biliary disease, including viral hepatitis,
alcoholic liver disease, primary biliary cirrhosis, and secondary sclerosing
cholangitis

- Patient with history of liver cirrhosis

- Patients with history of cholangiocarcinoma

- Patients who have received a liver transplant

- Patients currently enrolled in PSC clinical trials; and

- STEP II ONLY: Enrolled in or participated in Step I of this study (concept
elicitation)