Duration of Continuous Positive Airway Pressure and Pulmonary Function Testing in Preterm Infants
| Status: | Completed |
|---|---|
| Conditions: | Bronchitis, Hospital, Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases, Other |
| Healthy: | No |
| Age Range: | Any - 1 |
| Updated: | 11/17/2018 |
| Start Date: | September 2014 |
| End Date: | September 2017 |
The primary aim of this study is to quantify and compare changes in lung volumes (as measured
by functional residual capacity) in premature infants stable on continuous positive airway
pressure (CPAP), and then randomized to two additional weeks of CPAP and room air versus room
air alone. We hypothesize that infants randomized to additional CPAP will demonstrate an
increased functional residual capacity (at the end of the two week study period and prior to
discharge) compared to those randomized to room air.
by functional residual capacity) in premature infants stable on continuous positive airway
pressure (CPAP), and then randomized to two additional weeks of CPAP and room air versus room
air alone. We hypothesize that infants randomized to additional CPAP will demonstrate an
increased functional residual capacity (at the end of the two week study period and prior to
discharge) compared to those randomized to room air.
Inclusion Criteria:
- Gestational age at birth <33 weeks
- Required CPAP for a minimum of 24 hours for respiratory distress
- Patient on CPAP and room air at time of randomization
Exclusion Criteria:
- Complex congenital heart disease other than patent ductus arteriosus or atrial septal
defect
- Major malformations or chromosomal anomalies
- Multiple gestation greater than twins
- Culture proven sepsis or unstable at time of randomization
We found this trial at
1
site
3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
Portland, Oregon 97239
503 494-8311
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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