Exercise and Colon Cancer

Inclusion Criteria:

1. histologically confirmed TNM stage II-III CC;

2. completed surgical resection and adjuvant chemotherapy (if applicable) within 1-24
months before entering the study;

3. ≤120 min/wk of self-reported moderate or vigorous intensity physical activity using
the Paffenbarger physical activity questionnaire;

4. age ≥18 years;

5. written physician approval;

6. no additional surgery planned within the 6-month intervention (including colostomy
reversal);

7. ability to walk unaided for 6-minutes;

8. no contraindications to exercise using the PA readiness questionnaire (PAR-Q), unless
physician approves participation with specific knowledge of this contraindication.

Exclusion Criteria:

1. history of another primary invasive cancer (other than non-melanoma skin-cancer);

2. evidence of metastatic CC (i.e., TNM M1);

3. planning to receive any additional adjuvant chemotherapy;

4. pregnant or breast feeding;

5. unable to provide baseline blood sample;

6. cardiac conditions, including the following:

1. myocardial infarction or coronary revascularization procedure within prior 3
months;

2. uncontrolled hypertension (systolic ≥180 mmHg or diastolic ≥100 mmHg);

3. high-risk or uncontrolled arrhythmias;

4. clinically significant valvular disease;

5. decompensated heart failure;

6. known aortic aneurysm;

7. any other condition that may impede testing of the study hypothesis or make it unsafe
to engage in the exercise program (determined by the investigative team).