Effect of a Very Low Calorie and Low Calorie Diet on Moderate to Severe Obstructive Sleep Apnea in Obese Adults

Sleep apnea is a sleep disorder in which breathing repeatedly stops and starts during sleep.
The most common type is obstructive sleep apnea (OSA), which occurs when the muscles in your
throat relax and block your airway during sleep. The most noticeable sign of OSA is snoring.
OSA is a risk factor for other chronic conditions like type 2 diabetes, cardiovascular
disease, and high blood pressure.

Although anyone can develop OSA, it commonly affects people who are obese. The more someone
weighs, the more likely the OSA is to be severe. Weight loss is typically recommended for
overweight individuals to help improve OSA. However, not enough research has been done for
doctors to be able make specific recommendations to their patients.

Inclusion Criteria:

- AHI score of ≥ 5

- Body mass index (BMI) between 30 to 49.9 kg/m2

Exclusion Criteria:

- Report serious medical risk such as insulin-dependent diabetes, active cancer, recent
cardiac event

- Currently or planning to become pregnant during the next 9 months

- Not weight stable (-4.6 kg) for 3 mos. prior to intake

- Report current participation in a weight reduction program involving diet or PA

- Unwilling to be randomized to 1 of 3 study groups

- Report symptomology of an eating disorder as determined by the Eating Attitudes Test

- Unable to participate in moderate intensity physical activity