Assessment of Lung Structure and Function of Infants Born Prematurely
| Status: | Completed |
|---|---|
| Conditions: | Asthma, Bronchitis, Women's Studies |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases, Reproductive |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 1/19/2019 |
| Start Date: | January 2007 |
| End Date: | January 2019 |
The purpose of this study is to evaluate the growth of the lung and how easily gas can be
taken up by the lung in healthy infants born at full term without any breathing problems and
infants born prematurely.
taken up by the lung in healthy infants born at full term without any breathing problems and
infants born prematurely.
SPECIFIC AIM #1:
Determine the relationship between parenchymal tissue and alveolar volume with normal lung
growth early in life.
We hypothesize that during the first two years of life that parenchymal surface area and
alveolar volume increase with somatic growth; however, the ratio of surface area to volume
remains constant, while ventilation within the lung becomes more homogenous.
SPECIFIC AIM #2:
Determine the pulmonary sequelae of premature birth and assess the effectiveness of early
treatment strategies upon the pulmonary sequelae.
We hypothesize that premature birth impedes growth and development of the lung parenchyma and
the airways. In addition, initiating continuous positive airway pressure (CPAP) and a
permissive ventilatory strategy in very premature infants at birth will improve lung growth
and lung function compared to treatment with early surfactant and conventional ventilation.
Determine the relationship between parenchymal tissue and alveolar volume with normal lung
growth early in life.
We hypothesize that during the first two years of life that parenchymal surface area and
alveolar volume increase with somatic growth; however, the ratio of surface area to volume
remains constant, while ventilation within the lung becomes more homogenous.
SPECIFIC AIM #2:
Determine the pulmonary sequelae of premature birth and assess the effectiveness of early
treatment strategies upon the pulmonary sequelae.
We hypothesize that premature birth impedes growth and development of the lung parenchyma and
the airways. In addition, initiating continuous positive airway pressure (CPAP) and a
permissive ventilatory strategy in very premature infants at birth will improve lung growth
and lung function compared to treatment with early surfactant and conventional ventilation.
Inclusion Criteria:
Group 1:
- 37 weeks or greater gestational age
- Age 2 to 36 months
Group 2:
- 37 weeks or greater gestational age having a CT scan for non-respiratory issues.
- Age 2-36 months
Group 3:
- 23-35 weeks gestational age
Exclusion Criteria:
Group 1 and Group 2:
- Congenital cardio-respiratory disease
- Hospitalization for respiratory illness
- Treatment with asthma medications
- Small for gestational age at birth
Group 3:
- Congenital cardio-respiratory disease
- Severe developmental delay
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Riley Hospital for Children Riley Hospital for Children at IU Health is a place of...
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