Radiation Induced Cardiopulmonary Injury in Humans



Status:Active, not recruiting
Conditions:Hospital
Therapuetic Areas:Other
Healthy:No
Age Range:18 - Any
Updated:7/11/2018
Start Date:June 2008
End Date:July 2019

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Trial Summary
Trial Overview
Inclusion Criteria
The purpose of the study is to assess the time, dose dependence, and fraction-size dependence
of radiation (RT)-induced changes in regional lung and heart perfusion/function/structure
following thoracic RT delivered using newer IMRT/conformal/radiosurgery techniques. The PI
hopes to develop models to better relate and predict RT-induced changes in regional lung and
heart perfusion/function/structure with changes in global cardiopulmonary function. Patients
will undergo pre- and serial post-RT lung and heart assessments to better understand
RT-induced regional heart/lung changes.


Inclusion Criteria:

1. Age ≥ 18 years

2. Patients who are to receive 3D-planned RT for tumor within and around the thorax.

3. Patients receiving incidental RT to portions of the heart are eligible.

4. Estimated minimum expected life expectancy of one year

5. Able to undergo the required study-related tests for regional lung injury and regional
heart injury

6. Patients of child bearing potential age must have a negative pregnancy test and must
agree to use appropriate birth control measures while in the study.

7. Patients must be able to give informed consent. Informed consent will be obtained
prior to enrollment.

Exclusion Criteria:

1. Patients who are anticipated to have thoracic surgery post-RT are ineligible.

2. Patients with large mediastinal/hilar tumors compressing the airways/vessels, and
negatively impacting on cardiovascular function

3. Pregnant or nursing women.
We found this trial at
1
site
University of North Carolina at Chapel Hill, Department of Radiation Oncology
Chapel Hill, North Carolina 27599
Phone: 919-966-7700
?
mi
from
Chapel Hill, NC
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