A Phase 1 Study of MEDI4736 in Combination With Tremelimumab in Subjects With Advanced Solid Tumors
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - 99 |
| Updated: | 2/17/2019 |
| Start Date: | October 13, 2014 |
| End Date: | September 9, 2019 |
A Phase I Study of MEDI4736 (Anti-PD-L1 Antibody) in Combination With Tremelimumab (Anti-CTLA-4 Antibody) in Subjects With Advanced Solid Tumors
This is a multicenter, open-label, dose-exploration and dose-expansion study to evaluate the
safety, tolerability, antitumor activity, PK and immunogenicity of MEDI4736 in combination
with tremelimumab in subjects with select advanced solid tumors.
safety, tolerability, antitumor activity, PK and immunogenicity of MEDI4736 in combination
with tremelimumab in subjects with select advanced solid tumors.
Inclusion Criteria:
- Male and female subjects
- 18 years and older
- Histologic confirmation of advanced solid tumors
- Subjects must have recurrent/metastatic disease and may have been previously treated
in the recurrent/metastatic setting.
Exclusion Criteria:
- Any concurrent chemotherapy, immune-mediated therapy or biologic or hormonal therapy
for cancer treatment
- Active or prior documented autoimmune disease within the past 2 years
- Current or prior use of immunosuppressive medication within 14 days with some
exceptions.
We found this trial at
27
sites
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