Ranolazine Among Unrevascularized Chronic Stable Angina Patients

This is a prospective, double-blind, placebo-controlled, randomized, single-center (North
Florida- South Georgia VA Medical Center) study. The study objective is to determine if
ranolazine improves angina symptoms at 4 months compared with placebo among stable coronary
artery disease patients who have demonstrable myocardial ischemia, but who do not undergo
revascularization.

Baseline Procedure:

Assessments performed exclusively to determine eligibility for this study would be done only
after obtaining informed consent. Assessments performed for clinical indications (not
exclusively to determine study eligibility) may be used for baseline values even if the
studies were done before informed consent was obtained. The assessment will include:

- Informed Consent

- Review subject eligibility criteria

- FFR value calculated at the time of cardiac catheterization

- Review previous and concomitant medications

- Frequency of symptoms and quality of life prior to study according to Seattle Angina
Questionnaire (SAQ)

Screening Visit:

The assessments to determine eligibility are:

- Review of eligibility criteria

- Review of cardiac catheterization and FFR

- Review of medications taken in the past 30 days Subjects that meet eligibility criteria
will be randomized to receive either the active drug, Ranolazine or a matching placebo
(non-active drug). Staff and subjects will not know if the subject will be receiving the
active drug or the placebo.

Drug schedule will be as follows:

- 1st dose of one tablet (500mg) will begin the evening of Day 1

- On Days 2-7, one tablet (500mg) two times a day (12-hours apart).

- On Day 8, increase dose of study drug to two tablets (1000mg) twice a day; once in the
morning and once in the evening, 12 hours apart. This dose will continue for the
duration of the study. The study drug can be taken with or without food.

Telephone Follow-up:

One week phone calls will be made to determine well being, adverse events, answer questions
and remind subjects to increase the study medication dose.

Month 4 Follow-up:

- Frequency of symptoms and quality of life according to Seattle Angina Questionnaire
(SAQ)

- Assessment of well-being

- Any hospitalizations or the need for revascularization

Inclusion Criteria:

- Adult patients >= 18 years of age referred for cardiac catheterization for evaluation
of cardiac symptoms ( angina, fatigue, or shortness of breath)

- At least 1 indeterminate stenosis (20-80%),

- Fractional flow reserve (FFR) <=0.8 and PCI deferred

Exclusion Criteria:

- Coronary revascularization (percutaneous coronary intervention or coronary artery
bypass grafting) during the index procedure or anticipated within the next month

- acute coronary syndrome or cardiogenic shock

- QTc > 500 milliseconds

- use of strong inhibitors of CTP3A (i.e. ketoconazole, itraconazole,
clarithromycin,nefazodone, nelfinavir, ritonavir, indinavir and saquinavir)

- use of inducers of CYP3A (i.e. rifampin, rifabutin, rifapentine, phenobarbital,
phenytoin, carbamazepine, and St. John's wort)

- liver cirrhosis

- sever renal insufficiency (i.e. creatinine clearance < 30mL/min/1.73 m2)