Treatment of Chronic Itch in Atopic Dermatitis (Eczema)

This study will serve as a pilot study to determine the efficacy and safety of two novel oral
agents (clonidine, naltrexone) in the treatment of chronic, non-experimentally induced itch
in atopic dermatitis. In this study, eight subjects with symptomatic atopic dermatitis will
be recruited and treated with either oral clonidine (four subjects) or oral naltrexone (four
subjects) . Disease burden will be evaluated before and after 4 weeks of treatment through
reporting of subjective symptomatology via surveys/questionnaire, neurometer study, and
clinical assessment.

Inclusion Criteria:

1. Age range 18-70 years old and ability to give informed consent and HIPAA
authorization.

2. Female subjects of childbearing potential must have a negative pregnancy test, and
must agree to practice two methods of effective birth control during the study period
as clonidine is an FDA pregnancy category C drug (including abstinence, oral or
implant contraceptives or condoms).

3. Diagnosis of AD via simplified UK Working Group Criteria and a baseline PSGA score of
2 or greater

4. Willingness to adhere to study protocol

5. Subjects taking hormone-containing medications must be on a stable dose for 6 months
prior to study start to avoid any confounding influence on sensory and pain perception

Exclusion Criteria:

1. Use of topical or oral anti-inflammatory medications for 2 weeks prior to the study
start.

2. Use of topical or oral anti-histamines for 2 weeks prior to the study start.

3. Use of topical or oral anti-pruritic agents for 2 weeks prior to the study start.

4. Use of oral neuromodulatory agents for 2 months prior to study start.

5. Current use of chronic pain medications (including opioids, antidepressants and
anti-epileptic drugs).

6. Use of nicotine-containing products for the past 6 months prior to study start.

7. History of radiation or chemotherapy.

8. History of traumatic injury on prospective test sites.

9. Unstable thyroid function within the past 6 months prior to study start to exclude
thyroid-related neuropathy (Duyff et al, 2000).

10. Known history of central or peripheral nervous system dysfunction.

11. History of acute hepatitis, chronic liver disease or end stage liver disease.

12. History of human immunodeficiency virus (HIV) or acquired immune deficiency syndrome.

13. History of neuropathy associated with chronic obstructive pulmonary disease, diabetes
mellitus, documented exposure to organophosphates or heavy metals or polychlorinated
biphenyls.

14. Known nutritional deficiency (vitamin B12, vitamin D, iron or zinc) within 3 months
prior to the study start.

15. Use of illicit drugs within the past 6 months prior to study start.

16. History of daily use of power tools.

17. Lyme disease, porphyria, rheumatoid arthritis, Hansen's disease (leprosy) or use of
antineoplastic chemotherapeutic agents.

18. Subject has any medical condition that, in the judgment of the Investigator, would
jeopardize the subject's safety following exposure to the administered medications.

19. Adults lacking capacity to consent