Cognitive Motor Interference Rehabilitation in Persons With Multiple Sclerosis
| Status: | Recruiting |
|---|---|
| Conditions: | Neurology, Neurology, Multiple Sclerosis |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | 18 - 64 |
| Updated: | 4/21/2016 |
| Start Date: | October 2014 |
| End Date: | September 2016 |
| Contact: | Jacob Sosnoff, PhD |
| Email: | jsosnoff@illinois.edu |
| Phone: | 217-333-9472 |
This study examines the effect of balance and walking exercise on cognition and mobility in
people with Multiple Sclerosis.
people with Multiple Sclerosis.
Walking and cognitive impairments are common in persons with multiple sclerosis (MS).
Approximately 85% of persons with MS report walking as a major limitation, whereas 65%
experience cognitive dysfunction. Traditionally, walking and cognition have been viewed as
unrelated, but there is evidence of cognitive-motor interference (CMI). CMI is believed to
stem from damage to common neural tracts. Recent evidence supports cognitive-motor
interference in persons with MS. For example, there is evidence that walking performance
declines when performed in conjunction with a simultaneous cognitive task (i.e., dual task
cost [DTC] of walking) and this decline in walking performance is greater in persons with MS
compared to healthy controls. This elevated cognitive-motor interference during walking is
mainly associated with walking performance in persons with MS although cognitive function
does play a role. Cognitive-motor interference during mobility tasks is of practical and
clinical importance because it has been linked to decreased community mobility and a greater
risk of falls in other clinical populations. Despite the adverse consequences of elevated
CMI there is ambiguity concerning prevention and rehabilitation strategies for
cognitive-motor interference in individuals with MS.
This study seeks to examine whether single and/or targeted dual task rehabilitation has a
beneficial effect on CMI in individuals with MS. The results of this investigation will
provide the foundation for future rehabilitation-based randomized control trials seeking to
improve walking and cognitive function in persons with MS.
Approximately 85% of persons with MS report walking as a major limitation, whereas 65%
experience cognitive dysfunction. Traditionally, walking and cognition have been viewed as
unrelated, but there is evidence of cognitive-motor interference (CMI). CMI is believed to
stem from damage to common neural tracts. Recent evidence supports cognitive-motor
interference in persons with MS. For example, there is evidence that walking performance
declines when performed in conjunction with a simultaneous cognitive task (i.e., dual task
cost [DTC] of walking) and this decline in walking performance is greater in persons with MS
compared to healthy controls. This elevated cognitive-motor interference during walking is
mainly associated with walking performance in persons with MS although cognitive function
does play a role. Cognitive-motor interference during mobility tasks is of practical and
clinical importance because it has been linked to decreased community mobility and a greater
risk of falls in other clinical populations. Despite the adverse consequences of elevated
CMI there is ambiguity concerning prevention and rehabilitation strategies for
cognitive-motor interference in individuals with MS.
This study seeks to examine whether single and/or targeted dual task rehabilitation has a
beneficial effect on CMI in individuals with MS. The results of this investigation will
provide the foundation for future rehabilitation-based randomized control trials seeking to
improve walking and cognitive function in persons with MS.
Inclusion Criteria:Physician diagnosed MS, relapse free for 30 days, self reporting
problems with multitasking -
Exclusion Criteria:We will exclude all individuals with risk factors contra-indicative for
undertaking strenuous exercise. Participants will verbally respond to a health history
questionnaire. Those individuals who are asymptomatic and meet no more than one risk
factor threshold including family history of coronary heart disease, cigarette smoking,
hypertension, high cholesterol, diabetes, obesity, and sedentary lifestyle will be
considered at low risk and included for participation.
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