Tau Imaging in Professional Fighters



Status:Completed
Conditions:Alzheimer Disease
Therapuetic Areas:Neurology
Healthy:No
Age Range:18 - Any
Updated:4/15/2017
Start Date:December 2014
End Date:February 3, 2017

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Trial Summary
Trial Overview
Inclusion Criteria

18F-AV-1451 PET Imaging in Professional Fighters

Subjects enrolled in the Professional Fighters Brain Health Study (PFBHS) will receive
18F-AV-1451 to explore its use as a biomarker for brain injury related to repetitive head
trauma and to examine the relationship between clinical presentation and tau deposition.


Inclusion Criteria:

All Subjects

- Currently enrolled in the PFBHS protocol and have participated in a minimum of 10
professional fights

- Can tolerate Positron Emission Tomography (PET) scan procedures

- Have the ability to provide informed consent

Subjects with cognitive impairment

- Have subjective cognitive complaints or objective decline or impairment as determined
by the investigator

Exclusion Criteria:

- Have behavior dysfunction that is likely to interfere with imaging

- Are claustrophobic or otherwise unable to tolerate the imaging procedure

- Have current clinically significant cardiovascular disease or clinically significant
abnormalities on screening electrocardiogram

- A history of additional risk factors for Torsades de Pointes (TdP) or are taking
drugs that are known to cause QT-prolongation

- Have a current clinically significant infectious disease, endocrine or metabolic
disease, pulmonary, renal or hepatic impairment, or cancer

- Have had a non-study related radiopharmaceutical imaging or treatment procedure
within 7 days prior to the study imaging session

- Have current drug or alcohol dependence or alcohol dependence within the past 2 years
We found this trial at
1
site
Cleveland Clinic Lou Ruvo Center for Brain Health
Las Vegas, Nevada 89106
?
mi
from
Las Vegas, NV
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