Clinical Evaluation of 18F-AV-1451

Subjects should meet inclusion and exclusion criteria for the companion protocol in
addition to the criteria below.

Inclusion Criteria:

- Subjects who have a historical volumetric MRI as part of the companion study

Exclusion Criteria:

- Have clinically significant cardiac, hepatic, renal, pulmonary, metabolic, or
endocrine disturbances

- Have a screening ECG with QTc > 450 msec if male or QTc > 470 msec if female

- Have a history of additional risk factors for Torsades de Pointes (TdP) or are taking
drugs known to cause QT-prolongation. Patients with a prolonged QTc interval in the
setting of intraventricular conduction block may be enrolled with sponsor approval

- Have a history of drug or alcohol dependence within the last year, or prior prolonged
history of dependence unless approved by the sponsor

- Are females of childbearing potential who are not surgically sterile, not refraining
from sexual activity or not using reliable methods of contraception

- Have a history of relevant severe drug allergy or hypersensitivity

- Are patients who have received an investigational medication under an FDA IND protocol
within 30 days prior to the planned imaging session for this study

- Are patients with current clinically significant unstable medical comorbidities

- Are patients who have received a radiopharmaceutical for imaging or therapy within the
past 24 hours prior to the imaging session for this study