Radiation Therapy in Combination With Brachytherapy for Clinically Localized, Intermediate Risk Prostate Cancer
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Prostate Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 10/31/2018 |
| Start Date: | October 28, 2014 |
| End Date: | October 2019 |
Ultra-hypofractionated, Image-guided, Intensity-modulated Radiation Therapy in Combination With Brachytherapy for Clinically Localized, Intermediate Risk Prostate Cancer
The purpose of this study is to test the safety and side effects "of "ultra-hypofractionated"
radiation therapy when used after brachytherapy (radiation implants). This treatment delivers
a higher radiation dose with each treatment over a shorter period of time.
radiation therapy when used after brachytherapy (radiation implants). This treatment delivers
a higher radiation dose with each treatment over a shorter period of time.
Inclusion Criteria:
- Intermediate risk prostate cancer patients will be eligible for this study.
Intermediate risk grouping will be assessed per NCCN guidelines as:
- Pathologically-proven diagnosis of prostate adenocarcinoma
- PSA 10-20ng/mL or
- Gleason =7 or
- Clinical stage T2b/c
- Clinical stage T2b/c Additionally, patients will be required to meet the following
criteria
- Age ≥18
- KPS≥70
- Prostate volume ≤ 60cc (cytoreductive androgen deprivation therapy prior to
brachytherapy of ≤ 6 months duration will be allowed to achieve this goal). For
patients with a prostate volume between 50-60ccs, hormone therapy will be at the
discretion of the physician.
- International Prostate Symptom Score ≤15
Exclusion Criteria:
- Prior prostate surgery (including TURP)
- Prior history of chronic prostatitis or urethral stricture
- Inflammatory bowel disease
- Prior history of pelvic radiotherapy
- Unable to give informed consent
- Metastatic disease.
We found this trial at
5
sites
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1275 York Ave
New York, New York 10021
New York, New York 10021
(212) 639-2000
Principal Investigator: Marisa Kollmeier, MD
Phone: 212-639-3952
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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1000 N Village Ave
Rockville Centre, New York 11570
Rockville Centre, New York 11570
(516) 256-3600
Phone: 212-639-3952
Memorial Sloan-Kettering at Mercy Medical Center Memorial Sloan Kettering Cancer Center Rockville Centre provides state-of-the-art...
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