Alterations in Muscle After Total Knee Arthroplasty



Status:Recruiting
Conditions:Arthritis, Osteoarthritis (OA)
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:50 - 75
Updated:12/29/2018
Start Date:October 2014
End Date:October 2019
Contact:Maggie H Reineke
Email:maggie.reineke@ucdenver.edu
Phone:719-251-7533

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Trial Summary
Trial Overview
Inclusion Criteria

Alterations in Skeletal Muscle Gene Expression Following Total Knee Arthroplasty

The overall goals of this work are: 1) to elucidate alterations in gene expression and
downstream protein synthesis 2 weeks after Total Knee Arthroplasty (TKA) to better explain
quadriceps muscle atrophy after TKA and 2) understand the mechanisms responsible for improved
maintenance of muscle strength with Neuromuscular Electrical Stimulation (NMES) utilization.
Furthermore, this investigation seeks to expand previous findings regarding attenuation of
strength and functional performance deficits with NMES application to better understand how
altered gene expression influences muscle function.


Inclusion Criteria:

- 50 to 75 years of age

- Scheduled for unilateral TKA at University of Colorado Hospital

- Diagnosed with osteoarthritis

- Cognitive status that allows patients to consistently comprehend and repeat back
directions regarding the details of the study

Exclusion Criteria:

- Neurological, vascular or cardiac problems that significantly limit function

- BMI > 35

- Testosterone supplementation

- Pregnancy

- Anticoagulant therapy
We found this trial at
2
sites
Univeristy of Colorado Anschutz Medical Campus
Aurora, Colorado 80045
Principal Investigator: Victor Cheuy, PhD
Phone: 303-724-9590
?
mi
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Aurora, CO
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University of Colorado, School of Medicine
Aurora, Colorado 80045
Principal Investigator: Victor Cheuy, PhD
Phone: 303-724-9590
?
mi
from
Aurora, CO
Click here to add this to my saved trials