A Study to Evaluate Efficacy and Safety of Lifitegrast in Subjects With Dry Eye (OPUS-3)



Status:Completed
Conditions:Ocular, Ocular
Therapuetic Areas:Ophthalmology
Healthy:No
Age Range:18 - Any
Updated:1/11/2019
Start Date:November 6, 2014
End Date:October 5, 2015

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A Phase 3, Multicenter, Randomized, Double-masked, and Placebo-controlled Study Evaluating the Efficacy and Safety of a 5.0% Concentration of Lifitegrast Ophthalmic Solution Compared to Placebo in Subjects With Dry Eye Disease and History of Recent Artificial Tear Use

Evaluate the efficacy and safety of Lifitegrast in subjects with dry eye disease and a recent
history of artificial tear use.


Inclusion Criteria:

- Patient-reported history of Dry Eye Disease in both eyes.

- Use of over the counter artificial tears within the past 30 days.

- A negative urine pregnancy test for females and willingness to use adequate birth
control throughout the study.

- Able and willing to comply with all study procedures.

Exclusion Criteria:

- Presence of an ocular condition that could affect the study parameters such as active
ocular infections, ocular inflammation, glaucoma, or diabetic retinopathy;.

- Unwilling to stop wearing contact lenses during the study.

- LASIK or other ocular surgical procedures within 12 months prior to or during the
study.

- Use of prohibited medications

- Significant medical conditions that could affect the study parameters.
We found this trial at
41
sites
Doylestown, Pennsylvania 18902
2363
mi
from 98109
Doylestown, PA
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4901 Calhoun Road
Houston, Texas 77204
1894
mi
from 98109
Houston, TX
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Artesia, California 90701
976
mi
from 98109
Artesia, CA
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2079
mi
from 98109
Birmingham, AL
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Chandler, Arizona
1131
mi
from 98109
Chandler, AZ
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Chesterfield, Missouri 63017
1703
mi
from 98109
Chesterfield, MO
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Cleveland, Ohio 44115
2022
mi
from 98109
Cleveland, OH
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Cranberry Township, Pennsylvania 16066
2119
mi
from 98109
Cranberry Township, PA
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El Paso, Texas 79902
1377
mi
from 98109
El Paso, TX
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Hoffman Estates, Illinois
1704
mi
from 98109
Hoffman Estates, IL
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Houston, Texas 77055
1884
mi
from 98109
Houston, TX
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1890
mi
from 98109
Houston, TX
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Indianapolis, Indiana 46260
1862
mi
from 98109
Indianapolis, IN
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Inglewood, California 90301
967
mi
from 98109
Inglewood, CA
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Kansas City, Missouri 64111
1504
mi
from 98109
Kansas City, MO
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Lake Villa, Illinois
1696
mi
from 98109
Lake Villa, IL
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Las Vegas, Nevada 89148
878
mi
from 98109
Las Vegas, NV
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Las Vegas, Nevada 89119
873
mi
from 98109
Las Vegas, NV
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1914
mi
from 98109
League City, TX
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Lexington, Kentucky 40509
2005
mi
from 98109
Lexington, KY
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Louisville, Kentucky 40206
1941
mi
from 98109
Louisville, KY
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McLean, Virginia 22102
2314
mi
from 98109
McLean, VA
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Mission Hills, California
944
mi
from 98109
Mission Hills, CA
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Montebello, California 90640
966
mi
from 98109
Montebello, CA
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Nashville, Tennessee 37203
1971
mi
from 98109
Nashville, TN
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New Albany, Indiana 47150
1935
mi
from 98109
New Albany, IN
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New York, New York 10036
2401
mi
from 98109
New York, NY
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Newport Beach, California
995
mi
from 98109
Newport Beach, CA
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Poway, California 92064
1050
mi
from 98109
Poway, CA
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Rancho Cordova, California 95670
628
mi
from 98109
Rancho Cordova, CA
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Redding, California
486
mi
from 98109
Redding, CA
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Rockville Centre, New York 11570
2420
mi
from 98109
Rockville Centre, NY
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Saint Louis, Missouri 63141
1706
mi
from 98109
Saint Louis, MO
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9911 Kennerly Road
Saint Louis, Missouri 63128
1717
mi
from 98109
Saint Louis, MO
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San Antonio, Texas 78209
1784
mi
from 98109
San Antonio, TX
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San Antonio, Texas 78229
1779
mi
from 98109
San Antonio, TX
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San Diego, California
1065
mi
from 98109
San Diego, CA
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Union, Kentucky 41091
1964
mi
from 98109
Union, KY
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Wantagh, New York 11793
2426
mi
from 98109
Wantagh, NY
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Washington, Missouri
1686
mi
from 98109
Washington, MO
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Winchester, Massachusetts 01890
2479
mi
from 98109
Winchester, MA
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