A Study to Evaluate Efficacy and Safety of Lifitegrast in Subjects With Dry Eye (OPUS-3)



Status:Completed
Conditions:Ocular, Ocular
Therapuetic Areas:Ophthalmology
Healthy:No
Age Range:18 - Any
Updated:1/11/2019
Start Date:November 6, 2014
End Date:October 5, 2015

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A Phase 3, Multicenter, Randomized, Double-masked, and Placebo-controlled Study Evaluating the Efficacy and Safety of a 5.0% Concentration of Lifitegrast Ophthalmic Solution Compared to Placebo in Subjects With Dry Eye Disease and History of Recent Artificial Tear Use

Evaluate the efficacy and safety of Lifitegrast in subjects with dry eye disease and a recent
history of artificial tear use.


Inclusion Criteria:

- Patient-reported history of Dry Eye Disease in both eyes.

- Use of over the counter artificial tears within the past 30 days.

- A negative urine pregnancy test for females and willingness to use adequate birth
control throughout the study.

- Able and willing to comply with all study procedures.

Exclusion Criteria:

- Presence of an ocular condition that could affect the study parameters such as active
ocular infections, ocular inflammation, glaucoma, or diabetic retinopathy;.

- Unwilling to stop wearing contact lenses during the study.

- LASIK or other ocular surgical procedures within 12 months prior to or during the
study.

- Use of prohibited medications

- Significant medical conditions that could affect the study parameters.
We found this trial at
41
sites
Doylestown, Pennsylvania 18902
417
mi
from 43215
Doylestown, PA
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4901 Calhoun Road
Houston, Texas 77204
992
mi
from 43215
Houston, TX
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Artesia, California 90701
1968
mi
from 43215
Artesia, CA
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491
mi
from 43215
Birmingham, AL
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Chandler, Arizona
1654
mi
from 43215
Chandler, AZ
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Chesterfield, Missouri 63017
412
mi
from 43215
Chesterfield, MO
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Cleveland, Ohio 44115
127
mi
from 43215
Cleveland, OH
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Cranberry Township, Pennsylvania 16066
161
mi
from 43215
Cranberry Township, PA
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El Paso, Texas 79902
1425
mi
from 43215
El Paso, TX
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Hoffman Estates, Illinois
302
mi
from 43215
Hoffman Estates, IL
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Houston, Texas 77055
994
mi
from 43215
Houston, TX
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991
mi
from 43215
Houston, TX
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Indianapolis, Indiana 46260
167
mi
from 43215
Indianapolis, IN
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Inglewood, California 90301
1980
mi
from 43215
Inglewood, CA
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Kansas City, Missouri 64111
619
mi
from 43215
Kansas City, MO
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Lake Villa, Illinois
312
mi
from 43215
Lake Villa, IL
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Las Vegas, Nevada 89148
1767
mi
from 43215
Las Vegas, NV
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Las Vegas, Nevada 89119
1756
mi
from 43215
Las Vegas, NV
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993
mi
from 43215
League City, TX
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Lexington, Kentucky 40509
154
mi
from 43215
Lexington, KY
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Louisville, Kentucky 40206
185
mi
from 43215
Louisville, KY
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McLean, Virginia 22102
319
mi
from 43215
McLean, VA
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Mission Hills, California
1978
mi
from 43215
Mission Hills, CA
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Montebello, California 90640
1966
mi
from 43215
Montebello, CA
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Nashville, Tennessee 37203
333
mi
from 43215
Nashville, TN
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New Albany, Indiana 47150
189
mi
from 43215
New Albany, IN
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New York, New York 10036
478
mi
from 43215
New York, NY
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Newport Beach, California
1967
mi
from 43215
Newport Beach, CA
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Poway, California 92064
1938
mi
from 43215
Poway, CA
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Rancho Cordova, California 95670
2033
mi
from 43215
Rancho Cordova, CA
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Redding, California
2058
mi
from 43215
Redding, CA
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Rockville Centre, New York 11570
496
mi
from 43215
Rockville Centre, NY
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Saint Louis, Missouri 63141
408
mi
from 43215
Saint Louis, MO
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9911 Kennerly Road
Saint Louis, Missouri 63128
405
mi
from 43215
Saint Louis, MO
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San Antonio, Texas 78209
1135
mi
from 43215
San Antonio, TX
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San Antonio, Texas 78229
1138
mi
from 43215
San Antonio, TX
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San Diego, California
1951
mi
from 43215
San Diego, CA
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Union, Kentucky 41091
113
mi
from 43215
Union, KY
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Wantagh, New York 11793
503
mi
from 43215
Wantagh, NY
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Washington, Missouri
437
mi
from 43215
Washington, MO
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Winchester, Massachusetts 01890
640
mi
from 43215
Winchester, MA
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