A Study to Evaluate Efficacy and Safety of Lifitegrast in Subjects With Dry Eye (OPUS-3)



Status:Completed
Conditions:Ocular, Ocular
Therapuetic Areas:Ophthalmology
Healthy:No
Age Range:18 - Any
Updated:1/11/2019
Start Date:November 6, 2014
End Date:October 5, 2015

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A Phase 3, Multicenter, Randomized, Double-masked, and Placebo-controlled Study Evaluating the Efficacy and Safety of a 5.0% Concentration of Lifitegrast Ophthalmic Solution Compared to Placebo in Subjects With Dry Eye Disease and History of Recent Artificial Tear Use

Evaluate the efficacy and safety of Lifitegrast in subjects with dry eye disease and a recent
history of artificial tear use.


Inclusion Criteria:

- Patient-reported history of Dry Eye Disease in both eyes.

- Use of over the counter artificial tears within the past 30 days.

- A negative urine pregnancy test for females and willingness to use adequate birth
control throughout the study.

- Able and willing to comply with all study procedures.

Exclusion Criteria:

- Presence of an ocular condition that could affect the study parameters such as active
ocular infections, ocular inflammation, glaucoma, or diabetic retinopathy;.

- Unwilling to stop wearing contact lenses during the study.

- LASIK or other ocular surgical procedures within 12 months prior to or during the
study.

- Use of prohibited medications

- Significant medical conditions that could affect the study parameters.
We found this trial at
41
sites
Inglewood, California 90301
1176
mi
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Inglewood, CA
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4901 Calhoun Road
Houston, Texas 77204
573
mi
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Houston, TX
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Artesia, California 90701
1163
mi
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Artesia, CA
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683
mi
from
Birmingham, AL
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Chandler, Arizona
844
mi
from
Chandler, AZ
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Chesterfield, Missouri 63017
399
mi
from
Chesterfield, MO
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Cleveland, Ohio 44115
895
mi
from
Cleveland, OH
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Cranberry Township, Pennsylvania 16066
967
mi
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Cranberry Township, PA
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Doylestown, Pennsylvania 18902
1227
mi
from
Doylestown, PA
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El Paso, Texas 79902
642
mi
from
El Paso, TX
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Hoffman Estates, Illinois
593
mi
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Hoffman Estates, IL
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Houston, Texas 77055
565
mi
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Houston, TX
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569
mi
from
Houston, TX
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Indianapolis, Indiana 46260
643
mi
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Indianapolis, IN
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Kansas City, Missouri 64111
196
mi
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Kansas City, MO
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Lake Villa, Illinois
606
mi
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Lake Villa, IL
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Las Vegas, Nevada 89148
970
mi
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Las Vegas, NV
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Las Vegas, Nevada 89119
960
mi
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Las Vegas, NV
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590
mi
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League City, TX
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Lexington, Kentucky 40509
725
mi
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Lexington, KY
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Louisville, Kentucky 40206
660
mi
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Louisville, KY
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McLean, Virginia 22102
1118
mi
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McLean, VA
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Mission Hills, California
1176
mi
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Mission Hills, CA
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Montebello, California 90640
1161
mi
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Montebello, CA
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Nashville, Tennessee 37203
618
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Nashville, TN
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New Albany, Indiana 47150
653
mi
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New Albany, IN
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New York, New York 10036
1287
mi
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New York, NY
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Newport Beach, California
1161
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Newport Beach, CA
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Poway, California 92064
1129
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Poway, CA
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Rancho Cordova, California 95670
1273
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Rancho Cordova, CA
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Redding, California
1326
mi
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Redding, CA
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Rockville Centre, New York 11570
1305
mi
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Rockville Centre, NY
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Saint Louis, Missouri 63141
403
mi
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Saint Louis, MO
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9911 Kennerly Road
Saint Louis, Missouri 63128
407
mi
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Saint Louis, MO
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San Antonio, Texas 78209
572
mi
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San Antonio, TX
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San Antonio, Texas 78229
571
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San Antonio, TX
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San Diego, California
1143
mi
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San Diego, CA
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Union, Kentucky 41091
716
mi
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Union, KY
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Wantagh, New York 11793
1312
mi
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Wantagh, NY
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Washington, Missouri
374
mi
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Washington, MO
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Winchester, Massachusetts 01890
1440
mi
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Winchester, MA
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