Positron Lymphography Via Intracervical 18F-FDG Injection for Pre-surgical Lymphatic Mapping in Stage IB1 Cervical Cancer and High-grade Endometrial Cancer

Inclusion Criteria:

- The study population will include women with stage IB1 cervical cancer (any histologic
subtype) deemed eligible for surgery, and women with a clinical stage I high-grade
endometrial cancer planning to undergo surgical staging. High grade is defined by the
following:

- Uterine serous carcinoma

- Clear cell endometrial carcinoma

- Grade 3 endometrioid carcinoma

- Endometrial carcinosarcoma

- Clinical stage I grade 1-2 endometrial cancer also eligible with deep myoinvasion
≥ 50% shown on preop MRI and/or elevated preop CA-125 > 35 U/ml.

- Age ≥18 years

- Hemoglobin ≥10 g/dL

- Plasma albumin ≥3 g/dL

- GOG performance status ≤2

- Plasma glucose ≤200 mg/dL

- Plasma creatinine ≤1.6

- Well-controlled hypertension

- Medical clearance for surgery and considered an appropriate surgical candidate

- Negative serum pregnancy test, if of child-bearing potential

- If, based on surgeon's assessment, the patient is recommended to undergo surgical
staging for histologically confirmed endometrial cancer or if IB1 cervical cancer is
deemed eligible for surgical treatment of disease

- Participation in other research protocols does not exclude a patient from
participation in this study

Exclusion Criteria:

- Hemoglobin <10 g/dL

- Plasma albumin <3 g/dL

- GOG performance status >2

- Plasma glucose >200 mg/dL

- Renal insufficiency with plasma creatinine >1.6

- Uncontrolled hypertension

- Patient does not meet medical clearance for surgery and is not considered an
appropriate surgical candidate

- Pregnancy

For Stage 2:

- Patient who are unwilling or unable to undergo MRI including patients with
contraindications to MRI such as the presence of cardiac pacemakers of non-compatible
intracranial vascular clips, claustrophobia, inability to lie flat for the duration of
the study etc.

- Patients with a metallic hip implant or any other metallic implant or device in the
pelvis that might distort local magnetic field and compromise quality of MRI