Efficacy and Safety of Momelotinib Combined With Trametinib in Adults With Metastatic KRAS-mutated Non-Small Cell Lung Cancer (NSCLC) Who Have Failed Platinum-Based Chemotherapy Preceded by a Dose-finding Lead-in Phase

Key Inclusion Criteria:

- Individuals with KRAS-mutated metastatic or recurrent non-small cell lung cancer

- Radiologic documentation of disease progression

- Measurable disease per RECIST v1.1

- Adequate organ function defined as follows:

- Hepatic: Total conjugated bilirubin ≤ 1.25 x upper limit of normal (ULN);
aspartate transaminase (AST) and alanine transaminase (ALT) < 3 x upper limit of
normal (ULN) or < 5 x ULN in the setting of liver metastases

- Hematological: Absolute neutrophil count (ANC) ≥ 1.5 x 10^9/L, platelet ≥ 100 x
10^9/L, hemoglobin ≥ 9 g/dL

- Renal: Serum creatinine < 1.5 x ULN OR calculated creatinine clearance (CLcr) ≥
60 ml/min

- Adequate left ventricular ejection fraction (LVEF) ≥ 50%

- Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1

- Negative serum pregnancy test for females

Key Exclusion Criteria:

- Less than or equal to 3 weeks since receiving treatment with biologic, small molecule,
chemotherapy or other agent for non-small cell lung cancer and 28 days since any prior
immunotherapy (such as nivolumab)

- History of a concurrent or second malignancy, except for specified exceptions in the
protocol or any other cancer that has been in complete remission for ≥ 5 years

- Known positive status for human immunodeficiency virus (HIV)

- Chronic active or acute viral hepatitis A, B, or C infection or hepatitis B or C
carrier

- Presence of ≥ Grade 2 peripheral neuropathy

- Brain metastases, or spinal cord compression. Individuals with brain metastases are
allowed if they have been treated with irradiation or surgery, are clinically stable
without steroid treatment. Individuals with documented leptomeningeal disease are not
eligible

- A history of uveitis and/or scleritis

- Retinal pathology beyond normal age-related processes

- Evidence of a retinal vein occlusion on ophthalmological exam or a history of retinal
vein occlusion

- History of newly diagnosed or uncontrolled glaucoma/intraocular pressure > 21 mm Hg as
measured by tonography

- Use of daily and/or chronic oral or ocular steroids. Individuals must be off daily
steroids for at least 3 weeks prior to enrolling into the trial

- History of interstitial pneumonitis

- History of long QT syndrome or whose corrected QT interval (QTc) measured (Fridericia
method) at screening is prolonged (> 480 ms for males and females)

Note: Other protocol defined Inclusion/Exclusion criteria may apply