The Effect of Omega-3 Fatty Acid Supplementation on Intraocular Pressure & Ocular Surface
| Status: | Withdrawn |
|---|---|
| Conditions: | High Blood Pressure (Hypertension), Ocular |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Ophthalmology |
| Healthy: | No |
| Age Range: | 40 - 89 |
| Updated: | 4/21/2016 |
| Start Date: | November 2014 |
| End Date: | November 2015 |
This study is designed with the intention to further elucidate the effects of omega-3 fatty
acids on intraocular pressure (IOP) and signs/symptoms of dry eye. Prior studies have shown
statistically significant lowering of IOP with use of omega-3 fatty acids but have only been
performed in animal models. This study will be the first to attempt replication in human
models. A limited number of studies have shown an increase in tear production/volume as well
as a decrease in the subjective symptoms of dry eye, but more studies are needed to better
define these effects. Better understanding of the effects of this supplement on intraocular
pressure and dry eye will contribute to the expanding knowledge about the pathophysiology of
glaucoma/ocular hypertension and dry eye syndrome and potentially lead to further studies
about new potential treatment options for these conditions.
acids on intraocular pressure (IOP) and signs/symptoms of dry eye. Prior studies have shown
statistically significant lowering of IOP with use of omega-3 fatty acids but have only been
performed in animal models. This study will be the first to attempt replication in human
models. A limited number of studies have shown an increase in tear production/volume as well
as a decrease in the subjective symptoms of dry eye, but more studies are needed to better
define these effects. Better understanding of the effects of this supplement on intraocular
pressure and dry eye will contribute to the expanding knowledge about the pathophysiology of
glaucoma/ocular hypertension and dry eye syndrome and potentially lead to further studies
about new potential treatment options for these conditions.
The purpose of this research project is to determine the effects of omega-3 fatty acid
supplementation on intraocular pressure (IOP) as well as the signs and symptoms of dry eye.
We hypothesize that dietary omega-3 fatty acid supplementation will be associated with a
significant change in intraocular pressure compared to baseline measurements prior to
beginning supplementation. We further hypothesize that omega-3 fatty acid supplementation
will be associated with a significant increase in tear production and volume as well as a
significant change in patients' subjective complaints of dry eye.
supplementation on intraocular pressure (IOP) as well as the signs and symptoms of dry eye.
We hypothesize that dietary omega-3 fatty acid supplementation will be associated with a
significant change in intraocular pressure compared to baseline measurements prior to
beginning supplementation. We further hypothesize that omega-3 fatty acid supplementation
will be associated with a significant increase in tear production and volume as well as a
significant change in patients' subjective complaints of dry eye.
Inclusion Criteria:
- Diagnosis of Ocular Hypertension or Open Angle Glaucoma of mild to moderate severity,
with or without previously diagnosed dry eye syndrome, who are currently on
monotherapy with a prostaglandin analog.
- Age 40-89 of either gender, of any race/ethnicity
Exclusion Criteria:
- Females who are currently pregnant or planning to become pregnant during the study
period
- Age <40 years old
- Diagnosis of any other form of glaucoma other than open-angle
- Patients with known hypersensitivity (i.e., anaphylactic reaction) to omega-3 fatty
acids or any of its components
- Patients with cirrhosis or with known liver disease
- Patients with diagnosed celiac disease
- Patients with a hypersensitivity to fish or shellfish
- Patients with paroxysmal or persistent atrial fibrillation
- Patients who are currently using medical or recreational marijuana
- Patients currently on any anticoagulation therapy including warfarin, dabigatran,
apixaban, rivaroxaban, clopidogrel, cilostazol, dipyridamole, prasugrel, ticlopidine,
ticagrelor
- Patients currently on Lovaza, an omega- 3 fatty acid supplement requiring a
prescription
- Patients with any recent ocular surgery or laser treatment within 3 months
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