CeraVe Cream Compared to Desitin Paste for Treating Diaper Dermatitis in Infants

Visit 1 - Screening and Baseline Visit (Day 0) Subjects will be evaluated for study
eligibility using inclusion and exclusion criteria. The study doctor will assess diaper
dermatitis for inclusion and exclusion criteria and to verify mild to moderate severity. Once
study eligibility has been confirmed, parental/guardian consent will be obtained. No washout
period is necessary for this study.

Location of clinically apparent involved area will be shaded by hand onto diagram by the
research personnel. Study products will be dispensed to parent/caregiver, along with
instructions for administration. Parent/caregivers will also be asked to complete a daily
diary that asks about changes in their baby's diaper dermatitis, a Visual Analogue Scale
severity assessment of their baby's diaper dermatitis, and observations related to product
use and the baby's comfort level. Parents/caregivers will be asked to complete the daily
diary for each day of the study.

Visit 2 (Day 7) Subjects will again be assessed by the study doctor. Parent/caregiver will be
asked about any adverse effects in last 7 days.

Visit 3 - End of study (Day 14) Subjects will again be assessed by the study doctor. Daily
diaries and product will be collected at this time. Parent/caregiver will be asked about any
adverse effects in last 7 days. Parents/caregivers will also be given a questionnaire rating
the use of the study products.

Inclusion Criteria:

- Healthy children (except for diaper dermatitis) between 3 and 18 months of age

- Wearing diapers 24 hours per day

- Clinical irritant diaper dermatitis

- Received a Diaper Dermatitis severity score of 1.0 to 2.0 by investigator at screening
visit (mild-moderate severity)

- Parent/caregiver will not change type or brand of diaper during the study, although
the diaper type will be recorded

- No alteration of current product usage for creams, lotions, ointments, powders, soap,
laundry detergents, and fabric softeners

- A parent or guardian of minors must sign the approved Institutional Review Board
consent form prior to the conduct of any study-related procedures

Exclusion Criteria:

- Illness within past 4 days before study enrollment or any medical condition that may
affect risk of study participation

- Does not wear diapers 24 hours per day or currently being toilet trained

- Active diagnosis or history of dermatological conditions other than diaper rash that
may affect study

- Concomitant use of medications that may affect study (e.g., antifungal, topical
steroid, or topical calcineurin inhibitor)

- Previous allergic reaction or known sensitivity to ingredients in study agents