The Treatment of Progressive Early Onset Spinal Deformities: A Multi-Center Outcome Study

This multi-center study will evaluate the long-term clinical and radiographic outcomes of
Early Onset Scoliosis (EOS) and other Early Onset Spinal and Chest Wall Deformities in a
large population of patients.

The study will attempt to answer the following clinical questions:

1. How do clinical parameters (e.g. height, weight, pulmonary function, incidence of
complications) differ between:

1. Age groups

2. Etiologic groups

3. Treatment types including operative and non-operative methods

4. Patients who receive definitive spinal fusion versus those who do not

2. How do radiographic parameters (e.g. curve size, spinal height, thoracic dimensions,
sagittal profile, pelvic parameters, spinal balance) differ between:

1. Age groups

2. Etiologic groups

3. Treatment types including operative and non-operative methods

4. Patients who receive definitive spinal fusion versus those who do not

3. How does health-related quality of life (HRQOL), using the EOSQ-24 outcomes tool, differ
between:

1. Age groups

2. Etiologic groups

3. Treatment types including operative and non-operative methods

4. Patients who receive definitive spinal fusion versus those who do not

4. What demographic, clinical, radiographic, and surgical factors contribute to the
incidence of complications?

5. For patients with a particular diagnosis, age and/or treatment type, what are the
clinical, radiographic and HRQOL changes before and after treatment?

6. What are the mechanisms that cause rod breakage in growing rod constructs? (This study
question is a collaborative research study with the U.S. Food and Drug Administration).

Inclusion Criteria:

- Patients of any age and any diagnosis who undergo a growth-friendly surgical
procedure, including but not limited to growing rods, VEPTR, Shilla, hybrid
constructs, spinal tethering and staples

- Patients of any age and any diagnosis who undergo casting

- Patients of any diagnosis 10 years of age and younger who undergo spinal fusion of the
thoracic and/or lumbar spine

- Patients of any diagnosis under 6 years of age with scoliosis curves of the thoracic
and/or lumbar spine measuring > 25 degrees. Observed and braced patients included

Exclusion Criteria:

- Cervical spine anomalies alone will not be included

- Patient/family is unwilling to participate in the study