Bevacizumab and Bortezomib in Patients With Advanced Malignancy

Bevacizumab is an anti-cancer drug designed to prevent or slow down the growth of cancer
cells by blocking blood vessels that supply nutrients necessary for tumor growth.

Bortezomib is an anti-cancer drug designed to block the proteins needed for tumor growth.
This may cause cancer cells to die.

If you are found to be eligible to take part in this study, you will be enrolled into a
group of about 6 participants. The first group of participants will receive the lowest dose
of bevacizumab and bortezomib combined. The next group of participants will receive the next
highest dose of bevacizumab and bortezomib combined. This process will continue until the
study doctor finds the highest dose that can be tolerated. The dose that you receive will
depend on when you are enrolled in this study and the safety data that is available at that
time. The dose of bevacizumab and bortezomib that you receive may be lowered if you do not
tolerate the study drug combination well. You will not receive any doses of the study drug
higher than the dose you are first assigned to.

Bevacizumab and bortezomib will be given in "cycles." Cycles will be about 21 days long or
longer, depending on any side effects you may experience. During Cycle 1, Day 1, you will
receive bevacizumab by vein over 90 minutes. If bevacizumab is well tolerated in Cycle 1, it
will given over 60 minutes in Cycle 2. If it is well tolerated in Cycle 2, it will be given
over 30 minutes in Cycle 3. It will continue to be given over 30 minutes in further cycles
as long as the drug is still being well tolerated. Depending on which dose level you are
assigned to, you will receive bortezomib on Days 1 and 8, or on Days 1, 4, 8, and 11. You
will receive bortezomib by vein over about 1-5 minutes.

You will have blood drawn (about 1 tablespoon each time) for routine tests once a week
during Cycle 1. You will have a physical exam sometime between Days 7 to 14 during Cycle 1.
During the rest of the cycles, you will have a physical exam and blood drawn (about 1
tablespoon each time) for routine tests once every 3 weeks. The status of the disease will
be measured by a CT or MRI scan after every 2 cycles.

Once the highest tolerable dose (maximum tolerated dose or MTD) of the combination of
bevacizumab and bortezomib is found, up to 15 additional participants with advanced cancer
will be enrolled to receive that dose, so that researchers can learn more about the effects
of the study drugs on the tumor. A tumor biopsy will be required within two weeks before
the first treatment and again at the end of the first cycle for those patients. Up to 10
additional patients with kidney cancer will be enrolled to receive the highest tolerable
dose. Tumor biopsies are optional for patients with kidney cancer.

You may continue to receive bevacizumab and bortezomib on this study, unless the cancer gets
worse or you experience any intolerable side effects.

Once your participation is over in this study, you will receive standard of care follow-up
for the disease.

This is an investigational study. Bevacizumab and bortezomib are both FDA approved and
commercially available. Bevacizumab is FDA approved for the treatment of colorectal cancer.
Bortezomib is FDA approved for the treatment of multiple myeloma. The combination use of
bevacizumab and bortezomib is investigational and authorized for use in research only.

Up to 111 patients will take part in this study. All will be enrolled at MD Anderson.

Inclusion Criteria:

1. Patients with advanced or metastatic cancer that is refractory to standard therapy,
relapsed after standard therapy, or have no standard therapy that induces a CR rate
of at least 10% or improves survival by at least three months.

2. Patients must be >/= 6 weeks beyond treatment with nitrosoureas or mitomycin-C, >/= 4
weeks beyond other chemo- or radiotherapy, and must have recovered to toxicity for any treatment-limiting toxicity of prior therapy. (Exception: patients
who received palliative low dose radiotherapy to the limbs 1-4 weeks before this
therapy provided pelvis, ribs, sternum, scapulae, vertebrae or skull were not
included in the radiotherapy field). Patients who have received non-chemotherapeutic
biologic agents must wait 5 half-lives or 4 weeks, whichever is shorter, from the
last day of treatment.

3. ECOG performance status /= 60%).

4. Patients must have normal organ and marrow function defined as: leukocytes >/=
3,000/mL; absolute neutrophil count >/= 1,500/mL; platelets >/=75,000/mL; creatinine
with liver metastasis: total bilirubin
5. The effects of bevacizumab on the developing human fetus are unknown. Angiogenesis is
of critical importance to fetal development, and bevacizumab is likely to have
adverse consequences in terms of fetal development. For this reason, women of
child-bearing potential and men must agree to use adequate contraception (hormonal or
barrier method of birth control; abstinence) prior to study entry, for the duration
of study participation, and for 30 days after the last dose.

6. Ability to understand and the willingness to sign a written informed consent
document.

7. Life expectancy of at least 3 months.

Exclusion Criteria:

1. Patients with hemoptysis within 28 days prior to entering the study.

2. Patients with clinically significant unexplained bleeding within 28 days prior to
entering the study.

3. Uncontrolled systemic vascular hypertension.

4. Patients with clinically significant cardiovascular disease, including: history of
CVA within 6 months, myocardial infarction or unstable angina within 6 months,
unstable angina pectoris.

5. Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection requiring parenteral antibiotics on Day 1.

6. Pregnant or lactating women.

7. History of hypersensitivity to bevacizumab, murine products, or any component of the
formulation.

8. History of hypersensitivity to bortezomib, boron, mannitol, or any component of the
formulation.

9. (Only for the 10-patient expansion cohort after identification of the MTD): Patients
must be willing to undergo biopsy before treatment and at the end of cycle 1.