Methadone in Ambulatory Surgery



Status:Completed
Conditions:Post-Surgical Pain, Hospital, Hospital
Therapuetic Areas:Musculoskeletal, Other
Healthy:No
Age Range:18 - 65
Updated:2/17/2019
Start Date:December 2014
End Date:February 12, 2018

Use our guide to learn which trials are right for you!

Trial Summary
Trial Overview
Inclusion Criteria
The μ-opioid receptor agonist methadone is frequently used in adult anesthesia and adult pain
therapy. Methadone has an extremely long half-life, which confers therapeutic advantage by
providing more stable plasma concentrations and long-lasting pain relief. Methadone
perioperative pharmacokinetics and effectiveness in perioperative pain relief in inpatients
is well characterized. There is, however, no information on methadone use in an ambulatory
surgery setting and outpatient procedures. This pilot investigation will determine
effectiveness of intraoperative methadone in reducing postoperative opioid consumption and
providing improved pain relief in patients undergoing moderately painful, ambulatory surgical
procedures.


Inclusion Criteria:

- Age 18-65 years

- Undergoing general anesthesia and moderately painful, ambulatory surgical procedures
with anticipated overnight, postop hospital stay of < 24 hours

- Signed, written, informed consent

Exclusion Criteria:

- History of or known liver or kidney disease.

- Females who are pregnant or nursing.

- Opioid tolerant patients (e.g. preoperative methadone therapy or use of fentanyl
transdermal patches)

- History of allergy to methadone
We found this trial at
1
site
Barnes Jewish Hospital
Saint Louis, Missouri 63110
?
mi
from
Saint Louis, MO
Click here to add this to my saved trials