Development of a Novel Stress Testing Protocol to Define the Relationship Between Coronary Microvascular Dysfunction and Diastology in Women With Angina But No Evidence of Obstructive Coronary Artery Disease
| Status: | Recruiting |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - 60 |
| Updated: | 12/16/2018 |
| Start Date: | November 2014 |
| End Date: | December 2019 |
| Contact: | Ying Mou, PhD |
| Email: | ying.mou@cshs.org |
| Phone: | 310-248-7669 |
DEVELOPMENT OF A NOVEL STRESS TESTING PROTOCOL TO DEFINE THE RELATIONSHIP BETWEEN CORONARY MICROVASCULAR DYSFUNCTION AND DIASTOLOGY IN WOMEN WITH ANGINA BUT NO EVIDENCE OF OBSTRUCTIVE CORONARY ARTERY DISEASE
Microvascular coronary dysfunction (MCD) (abnormities in small blood vessels/arteries in
heart) with symptoms of persistent chest pain, primarily impacts women. There are an
estimated 2-3 million women in the US with MCD and about 100,000 new cases annually. Recent
data from our research group suggests that coronary microvascular disease impairs the way the
heart relaxes. This pilot study will attempt to exacerbate this phenotype in an effort to
better understand the pathophysiology of the disease. The investigators will recruit 30
volunteers total (10 healthy calibration subjects, 10 women with microvascular disease, and
10 age-match women for the group with microvascular disease). Subjects will undergo a series
of "stress" maneuvers in conjunction with advanced cardiac magnetic resonance imaging.
heart) with symptoms of persistent chest pain, primarily impacts women. There are an
estimated 2-3 million women in the US with MCD and about 100,000 new cases annually. Recent
data from our research group suggests that coronary microvascular disease impairs the way the
heart relaxes. This pilot study will attempt to exacerbate this phenotype in an effort to
better understand the pathophysiology of the disease. The investigators will recruit 30
volunteers total (10 healthy calibration subjects, 10 women with microvascular disease, and
10 age-match women for the group with microvascular disease). Subjects will undergo a series
of "stress" maneuvers in conjunction with advanced cardiac magnetic resonance imaging.
Inclusion Criteria:
1. Fully understanding and willing to undergo study procedures
2. Male or Female greater than or equal to 18 years of age
3. Understanding and willing to sign consent form.
Exclusion Criteria:
1. History of cardiovascular, pulmonary, or neurological disease
2. Hypertension (sitting blood pressure >140/90 mmHg, with measurements recorded on at
least 2 occasions)
3. Diabetes
4. Unable to give informed consent;
5. Contra-indication to CMRI testing, including claustrophobia and metallic implants
6. Adherence or retention issues;
7. Women who are pregnant.
8. Allergy to animal dander.
We found this trial at
1
site
8700 Beverly Blvd # 8211
Los Angeles, California 90048
Los Angeles, California 90048
(1-800-233-2771)
Phone: 310-248-7669
Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
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