Study Assessing Utility of a Clinical Questionnaire to Identify Subjects With Features of Both Asthma and Chronic Obstructive Pulmonary Disease (COPD)

The primary objective of the study is to identify demographic and non-spirometric clinical
features predictive of the asthma-COPD overlap population. The study aims to explore and
identify characteristics of the Asthma-COPD Overlap Syndrome (ACOS) patient's clinical
profile that enable clinical differentiation from subjects with a primary diagnosis of either
asthma alone (without persistent obstruction) or COPD alone (without reversibility). The
study is designed as a targeted medical history survey which consists of a 41-item
questionnaire, which will be administered by a qualified health care practitioner at the time
a subject's medical history is taken. The questionnaire has been developed to elicit specific
details of the respiratory history, including the following: bronchodilator use, disease
progression, variation in symptoms, atopic history, symptom triggers, vagal bias, burden of
disease, symptom presentation, co morbidities and age of onset. In addition, demographic
information, standard medical history, co morbidity and spirometric results will also be
obtained and analyzed in conjunction with the questionnaire results. Approximately 1000
subjects are required for the study.