Follow-up of AKI in Neonates During Childhood Years
| Status: | Recruiting |
|---|---|
| Conditions: | Renal Impairment / Chronic Kidney Disease |
| Therapuetic Areas: | Nephrology / Urology |
| Healthy: | No |
| Age Range: | 2 - 7 |
| Updated: | 4/21/2016 |
| Start Date: | December 2014 |
| End Date: | June 2016 |
| Contact: | Matthew W Harer, MD |
| Email: | mwh9g@virginia.edu |
| Phone: | 434-243-9470 |
Long Term Follow-up of Acute Kidney Injury in Very Low Birth Weight Infants
The purpose of this study is to learn more about how to identify signs of early chronic
kidney diseases in children who were born prematurely with low birth weight (less than 3 ½
pounds). Researchers plan to compare the kidney function in children who experienced acute
kidney injury (AKI) in the Neonatal Intensive Care Unit (NICU) with those who did not
experience it. Evidence from several studies and our experience at UVA show that older
children who experienced AKI while in the Pediatric Intensive Care Unit (PICU) have
increased risk of developing early chronic kidney disease, and they also show early changes
in the urine and blood that is consistent with early chronic kidney disease. In this study,
the investigators hope to determine if any of these changes can be detected in early
childhood, and if so, at what age we can start detecting these changes.
kidney diseases in children who were born prematurely with low birth weight (less than 3 ½
pounds). Researchers plan to compare the kidney function in children who experienced acute
kidney injury (AKI) in the Neonatal Intensive Care Unit (NICU) with those who did not
experience it. Evidence from several studies and our experience at UVA show that older
children who experienced AKI while in the Pediatric Intensive Care Unit (PICU) have
increased risk of developing early chronic kidney disease, and they also show early changes
in the urine and blood that is consistent with early chronic kidney disease. In this study,
the investigators hope to determine if any of these changes can be detected in early
childhood, and if so, at what age we can start detecting these changes.
Inclusion Criteria:
- Premature birth for Premature groups
- UVA NICU admission prior to 7 days of life
- Birth weight less than 1500 grams for premature groups
- Premature AKI Study group: Acute Kidney Injury as defined by KDIGO modified criteria
during NICU stay at UVA
- Premature no AKI Control group: No AKI during NICU stay
- Term no AKI Control group: No AKI and born at term
- Parental or legal guardian consent obtained
Exclusion Criteria:
- Patients with Congenital Anomalies of the Kidney and Urinary Tract
- SGA patients
We found this trial at
1
site
Charlottesville, Virginia 22903
(434) 924-0311
Principal Investigator: Jennifer Charlton, MD
Phone: 434-243-9470
University of Virginia The University of Virginia is distinctive among institutions of higher education. Founded...
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