Ketamine For Acute Treatment of Pain in Emergency Department
| Status: | Completed |
|---|---|
| Conditions: | Chronic Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 4/21/2016 |
| Start Date: | January 2015 |
| End Date: | November 2015 |
The aim of the study is to compare the safety & efficacy of low dose ketamine and morphine
versus morphine alone for acute generalized pain in the Emergency Department (ED). The
investigators are also interested to investigate whether low-dose ketamine is a safe and
effective alternative option to opioids for the acute treatment of pain in the Emergency
Department.
The agents that are available in the department includes acetaminophen, non-steroidal
anti-inflammatory (NSAIDS) and opioids. In most cases, acetaminophen and NSAIDS are not
adequate to manage acute pain crisis. There is also heightening concerns for increased
opioid use or abuse by patients. Since the HCAPHS survey includes various questions which
inquires about patient perception of pain management in the department, the investigators
are interested in investigating the safety and efficacy of low-dose ketamine to as an
alternative method to opioids for the acute management of pain. There has been limited,
mostly observational pilot studies, published in the literature. Limited data in the
literature have reported the incidence of nausea and vomiting ranged from 3-13%. All
published literature administered low-dose ketamine as an intravenous push. To the best of
our knowledge our study would be the first study to administer low-dose ketamine as a short
bolus infusion to mitigate the incidence of nausea and vomiting. The investigators believe
our study would provide important scientific data to fill the theoretical gap that low-dose
ketamine at 0.3mg/kg/dose may be a safe and effective agent for acute pain management in an
ED that is located in the center of a densely populated urban area.
versus morphine alone for acute generalized pain in the Emergency Department (ED). The
investigators are also interested to investigate whether low-dose ketamine is a safe and
effective alternative option to opioids for the acute treatment of pain in the Emergency
Department.
The agents that are available in the department includes acetaminophen, non-steroidal
anti-inflammatory (NSAIDS) and opioids. In most cases, acetaminophen and NSAIDS are not
adequate to manage acute pain crisis. There is also heightening concerns for increased
opioid use or abuse by patients. Since the HCAPHS survey includes various questions which
inquires about patient perception of pain management in the department, the investigators
are interested in investigating the safety and efficacy of low-dose ketamine to as an
alternative method to opioids for the acute management of pain. There has been limited,
mostly observational pilot studies, published in the literature. Limited data in the
literature have reported the incidence of nausea and vomiting ranged from 3-13%. All
published literature administered low-dose ketamine as an intravenous push. To the best of
our knowledge our study would be the first study to administer low-dose ketamine as a short
bolus infusion to mitigate the incidence of nausea and vomiting. The investigators believe
our study would provide important scientific data to fill the theoretical gap that low-dose
ketamine at 0.3mg/kg/dose may be a safe and effective agent for acute pain management in an
ED that is located in the center of a densely populated urban area.
The aim of the study is to compare the safety & efficacy of low dose ketamine and morphine
versus morphine alone for acute generalized pain in the Emergency Department (ED). The is a
randomized double blind placebo controlled trial to investigate the effects of low dose
ketamine and morphine versus placebo and morphine for the management of acute pain in the
ED.
versus morphine alone for acute generalized pain in the Emergency Department (ED). The is a
randomized double blind placebo controlled trial to investigate the effects of low dose
ketamine and morphine versus placebo and morphine for the management of acute pain in the
ED.
Inclusion Criteria:
- Patients 18 years old and older presenting with acute generalized pain
- Describes pain to be greater than or equal to 3 on the Visual Analogue Scale (VAS)
- Provides informed consent
Exclusion Criteria:
- Patients who are admitted to the hospital
- Severe hypertension(≥180/100)
- Presence of or suspected for traumatic head injury with or without loss of
consciousness
- Presence of or suspected for myocardial ischemia
- Presence of or suspected alcohol intoxication
- Hemodynamic instability
- History of schizophrenia
- History of Sickle cell crisis / presenting with acute sickle cell crisis
- History of or suspected recreational substance abuse
- History of or suspected diagnosis of headache or migraine
- History of or suspected diagnosis increase in intracranial/intraocular pressure
- Known or suspected pregnancy
- Allergy to ketamine or morphine
- Administration of opioids in previous 4 hours
- Patients with language barriers or in altered mental status who are unable to
describe pain
- Patients weighing over 166kg
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