DOXAZOSIN FOR PTSD

Inclusion Criteria:

1. Be male OIF/OEF veteran or active duty. Males only are included in this small pilot
study because we will not have sufficient sample size to analyze gender effects. Women
will be included in subsequent studies

2. Be aged between 18 and 55 years

3. Meet DSM-IV TR criteria for PTSD

4. Meet inclusion criteria for VRE participation

5. Have vital signs as follows: supine blood pressure > 100/65 mm Hg, a seated blood
pressure greater than 90/60 mm Hg, and an orthostatic change smaller than20 mm Hg
systolic or 10 mm Hg diastolic on standing. Participants should not have hypertension
(BP above 150/100)

6. Have hematology and chemistry laboratory tests that are within reference limits
(±10%), with the following exceptions: (a) total bilirubin must be less than 2x upper
limit of normal and ALT, AST, and alkaline phosphatase less than 3× the upper limit of
normal and (b) kidney function tests (creatinine and BUN) within normal limits

7. Have a baseline ECG that demonstrates clinically normal sinus rhythm, clinically
normal conduction, and no clinically significant arrhythmias

8. Have a medical history and brief physical examination demonstrating no clinically
significant contraindications for study participation, in the judgment of the
admitting physician and the principal investigator

Exclusion Criteria:

1. Have any history or evidence suggestive of seizure disorder or brain injury

2. Have neurological or psychiatric disorders, such as psychosis or bipolar illness as
assessed by Structural Clinical Interview for DSM disorders (SCID); clinically
significant organic brain disease or dementia or Axis I psychiatric illness other than
PTSD that would interfere with study; acceptable history of suicide attempts within
the past year and/or current suicidal ideation/plan

3. Have evidence of untreated or unstable medical illness including neuroendocrine,
autoimmune, renal, hepatic, or active infectious disease

4. Have HIV and are currently symptomatic or are taking antiretroviral medication

5. Have any other illness or condition which in the opinion of the PI and/or the
admitting physician would preclude safe and/or successful completion of the study

6. Dr. Newton (medical supervisor) will review potential participants' prescribed
medication to make a final decision on eligibility. We anticipate that participants
will be on a wide range of medications prescribed for PTSD. However, these treatments
will unlikely interact with the doxazosin effects of this study. We will not ask
participants to change their medications