Effects of Nicotine-Free Hookah Smoking on Blood Flow to the Heart, Muscle and Skin

Inclusion Criteria:

- 18 to 39 years of age

- Habitual Hookah smoker defined as having smoked Hookah >=12 times in the past 12
months

- Have not smoked cigarettes within the past 12 months

Exclusion Criteria:

- Exhaled carbon monoxide level greater than 10 ppm* as evidence of current or recent
cigarette (excluded if smoked cigarette within 12 months) or Hookah smoking (excluded
if smoked Hookah within past 72 hours)

- History of cardiopulmonary disease

- Use of any prescription medication with exception of oral contraceptive pills

- History of psychiatric illness

- History of neurologic disease

- BMI ≥ 35

- Evidence of any of the above by physical examination, ECG or echocardiogram

- Smoked cigarette in the past 12 months

- History of illicit drug use

- Pregnant

- Any other condition(s) deemed by the physician investigators that put subjects at
risk for participating in the study