Spinal Cord Neuromodulation for SCI

An epidural stimulation device will be tested to determine if motor function can be
improved.

Inclusion Criteria:

1. Stable medical condition without cardiopulmonary disease or dysautonomia that would
contraindicate hand/arm movement

2. No severe cardiopulmonary diseases such as severe bradycardia, severe autonomic
dysreflexia, and/or Chronic Obstructive Pulmonary Disease.

3. No painful musculoskeletal dysfunction, unhealed fracture, contracture, pressure
sore, or infection that might interfere with upper extremity training

4. No clinically significant depression or ongoing drug abuse

5. No current anti-spasticity medication regimen

6. Non-progressive SCI above C5

7. Must not have received botox injections in the prior six months

8. Be unable to grip or move independently

9. Be at least one-year post injury

10. Must be at least 18 years of age

11. Segmental reflexes remain functional below the lesion

12. Female subjects of child-bearing potential must not be pregnant and must be using a
medically acceptable method of contraception

13. No current implant(s) of neurostimulators, cardiac pacemakers, defibrillators,
shunts, stents, or aneurysm clips, and must have no future exposure to diathermy
following implantation

14. No coagulopathy, cardiac risk factors, or other significant medical risk factors for
surgery

15. Must not be involved in another clinical trial

16. Must not have disorders or conditions that would require MRI monitoring

Exclusion Criteria:

None as long as inclusion criteria are met.