Use of Hyperpolarized 129Xe MR Lung Imaging in Adults for Calibration

Hyperpolarized 129Xe will be produced, by trained staff, using a polarizer housed at
Cincinnati Children's Hospital Medical Center. Individual imaging sessions will be done on a
single day and will involve administration of (maximum) 1 liter doses for up to four MRI
scans. Subject will inhale hyperpolarized xenon gas and hold breath for up to 16 seconds
during the MRI scans. In addition to 129 Xe MRI, a series of anatomical conventional proton
MR images may also be collected. Follow up will be done one day and 30 days from the MRI
date.

Inclusion Criteria:

- Adults ages 18 years and older

- Participant must be able to hold their breath for up to 16 seconds

Exclusion Criteria:

- History of heart defect

- Pregnancy or positive pregnancy test

- History of uncontrolled asthma defined for this study as requiring use of rescue
inhaler ≥ 2 times in past month.

- Symptoms of respiratory infection (loose or productive cough or wheeze), chest
tightness, or sinus infection within past week.

- Baseline oximetry at MRI visit of less than 95% on room air or less than 95% on a
previously prescribed dosage of oxygen delivered by nasal cannula.

- Participant is claustrophobic and unable to tolerate the imaging.

- Standard MRI exclusions (metal, implants).