The Preventive Coronary Intervention on Stenosis With Functionally Insignificant Vulnerable Plaque

Sub-analysis for each imaging test will be performed as below ;

- NIRS(Near-infrared spectroscopy)

- OCT(Optical coherence tomography)

- VH-IVUS(IVUS-derived virtual histology)

- IVUS(Intravascular ultrasonography)

Inclusion Criteria:

- Age 18 years or older

- Symptomatic or asymptomatic coronary artery disease patients

- Patients having at least one significant stenosis (diameter stenosis > 50%) with FFR
>0.80 and meeting two of the following:

1. MLA(minimal luminal area)<4mm2

2. plaque burden>70%

3. Lipid-rich plaque on NIRS(Intracoronary Near-Infrared Spectroscopy) (defined as
maxLCBI4mm>315)

4. TCFA(thin-cap fibroatheroma) defined by OCT(fibrous cap thickness<65µm and
arc>90°) or VH-IVUS≥10% confluent NC with>30° abutting to the lumen in 3
consecutive slices)

- 2 target vulnerable lesions

- Eligible for percutaneous coronary intervention with Absorb Bioresorbable Vascular
Scaffold or Everolimus Eluting Stent

- Willing and able to provide informed written consent

- Reference vessel diameter 2.75-4.0

- Lesion length ≤ 40

Exclusion Criteria:

- Patients in whom the preferred treatment is CABG(Coronary artery bypass grafting)

- Stented lesion

- Bypass graft lesion

- The patients who have more than or equal to 3 target lesions

- 2 target lesions in the same coronary territory

- Heavily calcified or angulated lesion

- Bifurcation lesion requiring 2 stenting technique

- Contraindication to or planned discontinuation of dual antiplatelet therapy within 1
year

- Life expectancy less than 2 years

- Planned cardiac surgery or planned major non cardiac surgery

- Woman who are breastfeeding, pregnant or planning to become pregnant during the course
of the study