ENDEAVOUR: Phase 3 Multicenter Study of Revusiran (ALN-TTRSC) in Patients With Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC)



Status:Completed
Conditions:Cardiology, Hematology
Therapuetic Areas:Cardiology / Vascular Diseases, Hematology
Healthy:No
Age Range:18 - 90
Updated:7/20/2018
Start Date:December 2014
End Date:March 30, 2017

Use our guide to learn which trials are right for you!

Trial Summary
Trial Overview
Inclusion Criteria

A Phase 3 Multicenter, Multinational, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of ALN TTRSC in Patients With Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy (FAC)

The purpose of this study was to evaluate the safety and efficacy of revusiran (ALN-TTRSC) in
patients with transthyretin (TTR) mediated Familial Amyloidotic Cardiomyopathy. Dosing has
been discontinued; patients are being followed-up for safety.


Inclusion Criteria:

- Documented TTR mutation

- Amyloid deposits in cardiac or non-cardiac tissue

- Medical history of heart failure

- Evidence of cardiac involvement by echocardiogram

Exclusion Criteria:

- Has known primary amyloidosis (AL), leptomeningeal amyloidosis, non-FAC hereditary
cardiomyopathy, hypertensive cardiomyopathy, or cardiomyopathy due to valvular heart
disease

- Has known peripheral vascular disease affecting ambulation

- Has a Polyneuropathy Disability score >2

- Has a New York Heart Association (NYHA) classification of IV
We found this trial at
40
sites
Clinical Site
Dallas, Texas 75390
?
mi
from
Dallas, TX
Click here to add this to my saved trials
Clinical Trial Site
Anderlecht,
?
mi
from
Anderlecht,
Click here to add this to my saved trials
Clinical Site
Atlanta, Georgia 30322
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Clinical Trial Site
Aurora, Colorado
?
mi
from
Aurora, CO
Click here to add this to my saved trials
Clinical Trial Site
Bakersfield, California
?
mi
from
Bakersfield, CA
Click here to add this to my saved trials
Clinical Trial Site
Baltimore, Maryland
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
Clinical Trial Site
Beverly Hills, California
?
mi
from
Beverly Hills, CA
Click here to add this to my saved trials
Clinical Site
Boston, Massachusetts 02114
?
mi
from
Boston, MA
Click here to add this to my saved trials
Clinical Site
Boston, Massachusetts 02114
?
mi
from
Boston, MA
Click here to add this to my saved trials
Clinical Site
Boston, Massachusetts 02114
?
mi
from
Boston, MA
Click here to add this to my saved trials
Clinical Trial Site
Bronx, New York
?
mi
from
Bronx, NY
Click here to add this to my saved trials
Clinical Trial Site
Charleston, South Carolina
?
mi
from
Charleston, SC
Click here to add this to my saved trials
Clinical Site
Chicago, Illinois 60153
?
mi
from
Chicago, IL
Click here to add this to my saved trials
Clinical Site
Chicago, Illinois 60153
?
mi
from
Chicago, IL
Click here to add this to my saved trials
Clinical Site
Chicago, Illinois 60153
?
mi
from
Chicago, IL
Click here to add this to my saved trials
Clinical Site
Cleveland, Ohio 44195
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
Clinical Site
Cleveland, Ohio 44195
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
Clinical Trial Site
Columbus, Ohio
?
mi
from
Columbus, OH
Click here to add this to my saved trials
Clinical Trial Site
Detroit, Michigan
?
mi
from
Detroit, MI
Click here to add this to my saved trials
Clinical Trial Site
Durham, North Carolina
?
mi
from
Durham, NC
Click here to add this to my saved trials
Clinical Trial Site
Fort Worth, Texas
?
mi
from
Fort Worth, TX
Click here to add this to my saved trials
Clinical Site
Houston, Texas 77030
?
mi
from
Houston, TX
Click here to add this to my saved trials
Clinical Trial Site
La Mesa, California
?
mi
from
La Mesa, CA
Click here to add this to my saved trials
Clinical Site
Los Angeles, California 90033
?
mi
from
Los Angeles, CA
Click here to add this to my saved trials
Clinical Site
Nashville, Tennessee 37232
?
mi
from
Nashville, TN
Click here to add this to my saved trials
Clinical Trial Site
New Orleans, Louisiana
?
mi
from
New Orleans, LA
Click here to add this to my saved trials
Clinical Site
New York, New York 10032
?
mi
from
New York, NY
Click here to add this to my saved trials
Clinical Trial Site
Newark, New Jersey
?
mi
from
Newark, NJ
Click here to add this to my saved trials
Clinical Site
Philadelphia, Pennsylvania 19104
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
Clinical Site
Philadelphia, Pennsylvania 19104
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
Clinical Trial Site
Richmond, Virginia
?
mi
from
Richmond, VA
Click here to add this to my saved trials
Clinical Trial Site
Rochester, Minnesota
?
mi
from
Rochester, MN
Click here to add this to my saved trials
Clinical Trial Site
Rosedale, New York
?
mi
from
Rosedale, NY
Click here to add this to my saved trials
Clinical Study Site
Saint Louis, Missouri 63117
?
mi
from
Saint Louis, MO
Click here to add this to my saved trials
Clinical Trial Site
San Francisco, California
?
mi
from
San Francisco, CA
Click here to add this to my saved trials
Clinical Trial Site
Seattle, Washington
?
mi
from
Seattle, WA
Click here to add this to my saved trials
Clinical Trial Site
Stanford, California
?
mi
from
Stanford, CA
Click here to add this to my saved trials
Clinical Trial Site
Tampa, Florida
?
mi
from
Tampa, FL
Click here to add this to my saved trials
Clinical Trial Site
Torrance, California
?
mi
from
Torrance, CA
Click here to add this to my saved trials
Clinical Trial Site
Washington, District of Columbia 20422
?
mi
from
Washington,
Click here to add this to my saved trials