The Strong Brain Study
| Status: | Completed |
|---|---|
| Conditions: | Arthritis, Osteoarthritis (OA), Orthopedic |
| Therapuetic Areas: | Rheumatology, Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 60 - Any |
| Updated: | 4/17/2018 |
| Start Date: | July 2014 |
| End Date: | June 2017 |
A Pilot Study to Evaluate the Role of Brain Integrity on Post-hospital Sarcopenia
To evaluate operational aspects of studying pre to post surgery/hospitalization changes in
the integrity of a major white matter pathways and how these contribute to reductions in the
ability to produce forceful muscle contractions.
the integrity of a major white matter pathways and how these contribute to reductions in the
ability to produce forceful muscle contractions.
Hospitalization is a strong and independent risk factor for Sarcopenia. Older adults who are
hospitalized in the previous year experience greater losses of lean mass and muscle strength
than their non-hospitalized peers. Most of the research has focused on understanding muscle
atrophy as the cause of weakness. However, post-hospitalization muscle weakness is not solely
due to muscle atrophy— it explains less than 10% of the variance. The investigators propose
that the sequela of hospitalization (e.g. deconditioning, disease severity, etc.) reduces the
integrity of brain motor pattern that is used to produce forceful muscle contractions.
Evidence from the literature suggests that central nervous system impairments explain
approximately 60% of the variance in the loss in muscle strength observed following
hospitalization. However, while these findings have helped to move the field forward, the
measures lack spatial resolution. Accordingly, there remains a major gap in understanding
whether deterioration of specific brain motor tracts contribute to post-hospitalization
induced sarcopenia. The investigators intend to conduct a prospective cohort study to examine
the integrity of the cortical-spinal white matter tract in post-hospitalized older adults.
However, the investigators lack some essential elements in which to conduct this future
study. Therefore, this pilot study will refine the following: patient eligibility,
feasibility of collecting outcomes in patients, variances for statistical power, influence of
covariates, timeline, patient attrition rates, data analysis strategies and magnetic
resonance imaging protocol for mapping the cortical-spinal tract. The investigators will
accomplish these operational aims efficiently and cost-effectively by leveraging funding with
a newly awarded R01 by Dr. Catherine Price, which seeks to identify pre-surgical neuroimaging
biomarkers following total knee arthroplasty (TKA) (R01NR014181; IRB# 487-2012).
Specifically, the investigators will add measures of sarcopenia (muscle strength, mass and
gait) and assess the integrity of the cortico-spinal tract. Measures will be collected in 20
patients before and after hospitalization (prior to surgery, 3 months and 12 months
post-surgery) and 20 controls who are matched in age and disease severity at similar time
points. In summary, there are long-term impairments that result from hospitalization in older
adults that are not explained by the illness alone. This pilot study will result in
subsequent larger NIH funded studies because the research is distinct from all others being
conducted on muscle function, aging and effects of hospitalization.
hospitalized in the previous year experience greater losses of lean mass and muscle strength
than their non-hospitalized peers. Most of the research has focused on understanding muscle
atrophy as the cause of weakness. However, post-hospitalization muscle weakness is not solely
due to muscle atrophy— it explains less than 10% of the variance. The investigators propose
that the sequela of hospitalization (e.g. deconditioning, disease severity, etc.) reduces the
integrity of brain motor pattern that is used to produce forceful muscle contractions.
Evidence from the literature suggests that central nervous system impairments explain
approximately 60% of the variance in the loss in muscle strength observed following
hospitalization. However, while these findings have helped to move the field forward, the
measures lack spatial resolution. Accordingly, there remains a major gap in understanding
whether deterioration of specific brain motor tracts contribute to post-hospitalization
induced sarcopenia. The investigators intend to conduct a prospective cohort study to examine
the integrity of the cortical-spinal white matter tract in post-hospitalized older adults.
However, the investigators lack some essential elements in which to conduct this future
study. Therefore, this pilot study will refine the following: patient eligibility,
feasibility of collecting outcomes in patients, variances for statistical power, influence of
covariates, timeline, patient attrition rates, data analysis strategies and magnetic
resonance imaging protocol for mapping the cortical-spinal tract. The investigators will
accomplish these operational aims efficiently and cost-effectively by leveraging funding with
a newly awarded R01 by Dr. Catherine Price, which seeks to identify pre-surgical neuroimaging
biomarkers following total knee arthroplasty (TKA) (R01NR014181; IRB# 487-2012).
Specifically, the investigators will add measures of sarcopenia (muscle strength, mass and
gait) and assess the integrity of the cortico-spinal tract. Measures will be collected in 20
patients before and after hospitalization (prior to surgery, 3 months and 12 months
post-surgery) and 20 controls who are matched in age and disease severity at similar time
points. In summary, there are long-term impairments that result from hospitalization in older
adults that are not explained by the illness alone. This pilot study will result in
subsequent larger NIH funded studies because the research is distinct from all others being
conducted on muscle function, aging and effects of hospitalization.
Inclusion Criteria:
- Aged 60 years old or older with no upper limit at time of baseline assessment
- Right handed; restriction due to left-right hemisphere laterality and white matter
pathways
- Able to understand and speak English
- Willing to give informed consent
Exclusion Criteria:
- Any conditions that pose health risk with physical exertion during a strength test as
discovered on a medical history (e.g. heart failure, surgical complications etc.)
- Cancer requiring treatment in past 5 years (exception: non-melanoma skin cancer)
- Serious infectious diseases (e.g., self-reported HIV, sepsis)
- Myocardial infarction/ CVA within last six months
- Congestive heart failure (NY stage III or IV)
- Chronic hepatitis
- History of organ transplantation
- Seizure disorders
- History of head trauma resulting in intensive care
- Current diagnosis of alcoholism
- Drug dependence, or a history of major tranquilizer use
- History of major stroke(s)
- Exposure to toxins or neuroleptics
- History of encephalitis
- Neurological signs of upper motor neuron disease, cerebellar involvement, supranuclear
palsy, or orthostatic hypertension that causes fainting
- Major Depression or Major Depressive Episode within three months prior to study
- Claustrophobia
- Non-medical bodily metal
- Pace-maker device
- Less than five years of formal education
- Inability to read or write
- Self-reported hearing or vision impairment that interferes with standardized test
administration
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