Efficacy of D-Cycloserine for Enhancing the Effects of CBT for Substance Use

This is a placebo-controlled trial of the efficacy of 50mg d-cycloserine or matching pill
placebo for enhancing the efficacy of CBT.

Inclusion criteria:

The primary selection criteria include women and men between the ages of 18 and 65 who:

1. Meet DSM-IV criteria for opiate dependence,

2. Maintain a stable dose of methadone for two weeks prior to recruitment and:

- fail to achieve "take-home" status for methadone dosing during at least the first
four months of methadone treatment,

- test positive on at least two toxicology screens for illicit drugs during the
month prior to recruitment

- have never achieved two consecutive toxicology screens free of illicit substances
since entering the current treatment episode.

3. Meet study criteria for chronic stress:

- unemployment criteria, and

- affective disorder criteria.

Exclusion Criteria:

1. Patients with significantly unstable or uncontrolled medical illness which may
interfere with participation in treatment (e.g., patients likely to require
hospitalization during the study period).

2. Patients with a psychotic or organic mental disorder according to DSM-IV criteria.

3. Patients receiving medication affecting methadone metabolism (e.g. rifampin).

4. Patients with uncontrolled bipolar disorder as evidenced by meeting current criteria
for mania or hypomania or meeting criteria for rapid cycling in the last year (as
indicated by structured questioning of all patients meeting criteria for bipolar
disorder).

5. Patients unable to complete the informed consent or unable to understand study
procedures in the informed consent process.

6. Pregnancy or current alcohol use.