Effect of High Doses of Radiation on Bone Structure and Metabolism

Participants in the Surgical Arm of the study will be treated according to the schedule
outlined in protocol for a combined treatment with surgery and adjuvant high dose
radiotherapy. Patients in the non surgical arm of the the study will be treated according to
the protocol being treated with radiotherapy alone.

Inclusion Criteria:

- All laboratory tests that are a part of the eligibility criteria must be completed
within 14 days prior to the date of registration. Diagnostic tests that are a part of
the eligibility criteria must be performed within 30 days of the date of registration.
Participants must meet the following criteria on screening examination to be eligible
to participate in the study:

- Study participants must have histologically confirmed primary malignant bone tumor in
the sacrum for which surgery and radiation or radiation alone are planned.

- Age 18 years or older. In children under the age of 8, tetracycline derivatives have
been reported to stain tooth enamel yellow color. These considerations lead us to
exclude young persons under the age of 18 from the study.

- Participants must have normal organ and marrow function as defined below:

- Total bilirubin within normal institutional limits

- Aspartaataminotransferase (AST) (SGOT)/ Alanine-aminotransferase (ALT) (SGPT) <
2.5 X institutional upper limit of normal

- Creatinine within normal institutional limits or creatinine clearance > 60
mL/min/1.73 m2 for subjects with creatinine levels about institutional normal
limit

- The effects of tetracyclines and radiation used in computer tomography on the
developing human fetus are known to be detrimental. For this reason, women of
child-bearing potential and men must agree to use adequate contraception (hormonal or
barrier method of birth control; abstinence) prior to study entry and for the duration
of study participation. Should a woman become pregnant or suspect she is pregnant
while participating in this study, she should inform her treating physician
immediately.

- Participants must be able to read and understand English language and have the ability
to understand and the willingness to sign a written informed consent document.

Exclusion Criteria:

Participants who exhibit any of the following conditions at screening will not be eligible
for admission into the study.

- Participants who have had surgery, chemotherapy, or radiotherapy of the sacrum prior
to entering the study

- History of allergic reactions attributed to compounds of similar chemical or biologic
composition to tetracyclines.

- Pregnant or nursing

- Uncontrolled inter current illness including, but not limited to ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements