Post-Operative Pain Control in Opioid Tolerant Patients: Fentanyl Challenge Protocol Versus Standard of Care
| Status: | Withdrawn |
|---|---|
| Conditions: | Post-Surgical Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | August 2014 |
This study will evaluate the value of dosing pain medications based upon a patient's
pre-operative tolerance to pain medications. Study participants will be assigned to one of
two groups, a treatment group and a control group. The treatment group will be given pain
medications after surgery based upon their measured response to pain medications prior to
surgery. The control group will be given pain medications based upon the normal dosing
routine as is currently practiced. Both groups will be closely monitored for side effects
and have their pain scores recorded for the first 48 hours following surgery.
pre-operative tolerance to pain medications. Study participants will be assigned to one of
two groups, a treatment group and a control group. The treatment group will be given pain
medications after surgery based upon their measured response to pain medications prior to
surgery. The control group will be given pain medications based upon the normal dosing
routine as is currently practiced. Both groups will be closely monitored for side effects
and have their pain scores recorded for the first 48 hours following surgery.
This study will focus on patients who are opioid-tolerant pre-operatively, a patient
population which typically has both higher pain scores and more complications related to
analgesics than opioid naïve patients. Currently, there is no standardized system for
determining an adequate pain control regimen for a patient post-operatively. At this
institution, pain medications are dosed per physician preference. The most widely-discussed
method for calculating tolerance to opioids relies on converting a patient's daily opioid
consumption to a morphine equivalent dose and basing a pain regimen upon that number. This
method does not account for variability of response to different medications or dosing forms
however. It would be advantageous to have a method of dosing opioid pain medications in this
population that is both safe and effective.
population which typically has both higher pain scores and more complications related to
analgesics than opioid naïve patients. Currently, there is no standardized system for
determining an adequate pain control regimen for a patient post-operatively. At this
institution, pain medications are dosed per physician preference. The most widely-discussed
method for calculating tolerance to opioids relies on converting a patient's daily opioid
consumption to a morphine equivalent dose and basing a pain regimen upon that number. This
method does not account for variability of response to different medications or dosing forms
however. It would be advantageous to have a method of dosing opioid pain medications in this
population that is both safe and effective.
Inclusion Criteria:
1. Age > 18
2. Anticipated need for PCA dosing post-operatively
3. Will undergo major general, plastic, vascular, thoracic or spine surgery
4. Have taken opioid medications orally or transdermally daily for the past 30 days
Exclusion Criteria:
1. Patients assessed to have a difficult airway
2. Known sensitivity or allergy to fentanyl
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