A Placebo Controlled Study of MR901 (Talaporfin Sodium Sodium + a Drug-activating Device) for the Relief of Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia

At least 192 patients with moderate-to-severe LUTS caused by BPH will be randomized in a
2:2:1:1 ratio to receive a single treatment of talaporfin sodium activated by light at one of
two light doses or placebo (saline) with light at either dose. Follow-up is planned for 52
weeks from the day of treatment, with assessment at 12 weeks for change in International
Prostate Symptom Score and continued follow-up during the remaining 40 weeks to assess
duration of effect, need for any intervention, and longer-term safety.

Inclusion criteria:

1. Males aged ≥40 years, weighing ≤200 Kg and able to provide written, informed consent.

2. Documented symptoms of BPH-LUTS for 6 months or more.

3. For patients regularly taking their prescribed BPH medication, dose should have been
stable for at least 6 months for 5-alpha reductase inhibitors and 3 months for other
BPH medications.

4. For patients who have withdrawn from regularly taking their prescribed BPH medication,
there should have been a 6 month washout period for 5-alpha reductase inhibitors and 3
months for other BPH medications.

5. Have a total International Prostate Symptom Score (IPSS; Qs 1-7) of ≥ 15 at both V1
and V2 with a difference between those visits of ≤ 4 points.

6. Prostate volume of 30 - 80 mL (inclusive).

7. Maximum urinary flow rate (Qmax): 5 - 15 mL/sec (assessed on two voids each of ≥
150mL).

8. Prostate-specific antigen (PSA) ≤10 ng/mL.

9. Post-void residual (PVR) volume ≤200 mL measured by a urinary catheter or bladder
ultrasound according to local standard practice.

10. Prostatic urethral length (PUL) of between 30 - 55mm (inclusive) as measured by TRUS.

11. Willing and able to comply with photosensitivity precautions

Exclusion criteria

1. Any minimally invasive or surgical treatment within the last 12 months, and is not
currently undergoing intraprostatic injections for BPH or any other prostatic
condition. In any case, all enrolled subjects must have, at Baseline cystoscopy, an
appearance/presentation of the prostate that is consistent with BPH and compatible
with possible response to the study test treatment.

2. Subjects weighing >200 Kg.

3. Subjects with a history or current evidence of any of the following:

1. A bladder disease or condition co-exists, such as idiopathic over-active bladder
(OAB) and is evaluated by the Investigator as the predominant etiology for the
subject's voiding symptomatology. A score of 4 points or greater on the 3 item
OAB Awareness Tool (OABV3) or a high rate of urinary frequency (>13xday and/or
4x/night) would require investigator specific evaluation in ascribing these
symptoms to a bladder condition as opposed to lower urinary tract obstruction. i)
If the former is the assessment, then the subject requires exclusion from the
study. ii) If the latter is the assessment, then the subject may be deemed
eligible for inclusion.

The subject eligibility explanation must be captured in the patient source
documents.

2. Active urinary tract infection i.e. must have a screening urinalysis without
signs of infection or negative urine culture. Must not have had a previous
symptomatic urinary tract infection within 4 weeks of the study.

3. Urethral stricture or any other anatomical feature that would complicate
catheterisation.

4. Interstitial cystitis.

5. Predominant prostate middle lobe, as determined by the Investigator.

6. Prostate or bladder cancer or bladder carcinoma-in-situ - in particular, evidence
from digital rectal exam (DRE) of prostate abnormalities suggestive of cancer in
the last 12 months.

7. Any other absolute indication for urosurgical intervention (such as acute or
frequent retention, currently untreated bladder or urethral stones, urethral
strictures/bladder neck contracture (BNC)).

8. Damage to the bladder neck which could interfere with study procedures.

4. PSA level in excess of >10 ng/ml. If the PSA measurement is 2.5-10 ng/ml and/or has
shown a clinically significant concerning increase in the last 6 months, local
standard of care must be pursued to ensure the possibility of prostate cancer has been
followed up and ruled out prior to study entry.

5. Subjects who had had a prostate biopsy within 6 weeks prior to Screening.

6. Any neurological condition affecting the bladder or a history of a neurogenic or
chronically decompensated bladder i.e. neurogenic bladder, Parkinson's disease,
history of chronic prostatitis within the last 5 years.

7. Prior treatment for urinary incontinence.

8. Requirements for daily incontinence pads or devices.

9. Subjects in whom nocturia is due to etiologies other than their BPH-LUTS, such as
neurogenic bladder, diabetic neuropathy, neurocongestive heart failure, hepatic
failure, nephritic syndrome, sleep disorder.

10. Previous or concurrent clinically relevant cardiovascular or cerebrovascular disorder
within 24 weeks prior to the study i.e. unstable angina pectoris, myocardial
infarction, transient ischemic attack, or cerebrovascular accident (stroke) within the
past 6 months, or peripheral arterial disease with intermittent claudication or
Leriche's syndrome.

11. Presence of serious hepatic diseases, renal diseases, immunological diseases, or
pulmonary diseases that are clinically relevant.

12. Unwilling to use contraception for 3 months following administration of study
medication or with an interest in future fertility.

13. A prolonged QTcF interval at baseline and/or who are currently taking medication that
prolongs QT interval ("prolonged QTcF interval" defined as > 450 ms).

14. Known sensitivity to porphyrin-type drugs or known history of porphyria.

15. Any contraindications to use of the study treatment.

16. Active alcohol or drug abuse.

17. Subject has clinical laboratory test results outside the reference ranges of the
testing laboratory that are deemed to be clinically significant. Subjects with
isolated test results that are outside the specified ranges and that are assessed as
clinically insignificant will be allowed at the discretion of the Investigator, after
discussion with the Sponsor's Medical Monitor/Study Physician, if appropriate. If a
subject has 1 isolated test result outside the specific range that is deemed
potentially clinically significant, rescreening may be allowed at the discretion of
the Investigator, after discussion with the Medical Monitor/Study Physician

18. Subjects with known disorders of coagulation, apart from those receiving anticoagulant
/ antithrombotic / antiplatelet therapy in whom the dose of such medication must have
been stable for at least 1 month prior to randomisation. In those receiving Vitamin K
antagonists (warfarin, acenocoumarol, phenindione, etc) the INR value at baseline
should be <3.0.

19. Inability or unwillingness to comply with the required photosensitivity precautions
during the three weeks following study treatment.

20. Subjects taking medications with a recognised propensity for causing photosensitivity
(such as amiodarone, tetracyclines, sulphonamides) that cannot be discontinued for the
initial study period, namely from 14 days prior to administration of study medication
until 28 days afterwards.

21. Subjects with medical or investigation results deemed unfit for study treatment, as
determined by medical history, clinical laboratory tests, ECG results, and physical
examination that, in the Investigator's opinion, preclude entry into the study.

22. Subjects who have received an investigational medicinal product within 30 days or 5
half-lives of the investigational product prior to study entry (defined as the start
of the Screening Period).

23. Subjects who are incapable of giving informed consent or complying with the protocol.