Phenotype, Genotype & Biomarkers in ALS and Related Disorders

This study will recruit patients with ALS, ALS-FTD, PLS, HSP, and PMA, with a focus on
incident cases. Patients with both familial and sporadic forms of these diseases will be
enrolled and followed longitudinally using a standardized set of evaluations. Biological
samples (blood, urine, CSF) will be collected from all study participants, and will be used
for biomarker discovery and validation. Family members of affected individuals may also be
enrolled and asked to contribute DNA and biological samples to aid genetic and biomarker
discovery.

Inclusion Criteria:

- Member of at least one of the following categories:

1. Individuals with a clinical diagnosis of ALS or a related disorder, including
FTD, HSP, PLS, PMA and MSP (sporadic or familial).

2. Family member of an enrolled affected individual.

- Able and willing to comply with relevant procedures.

Exclusion Criteria:

- Affected with end or late stage disease.

- A condition or situation which, in the PI's opinion, could confound the study finding
or may interfere significantly with the individual's participation and compliance with
the study protocol. This includes (but is not limited to) neurological, psychological
and/or medical conditions.