Central Corneal Swelling With Silicone Hydrogel Materials

Inclusion Criteria:

1. The participant must be at leat 18 years old or older and no greater than 65 years
old. Children younger than18 will likely no be able to come back and forth to the
clinic during the typical work week as outlined in the above (due to school schedules)
and thus not be able to adhere to the protocol.

2. The participant must be a current soft contact lens wearer who routinely wears lenses
at least 6-8 hours per day and at least 4 days per week for at least the past 3
months.

3. Refraction suitable for spherical soft contact lens powers between -1.00 and -6.00 D
the participant must be correctable to 20/30 or better at distance with both eyes with
dispensed contact lenses.

4. The participant must be free of any active anterior segment disorders that would
preclude safe contact lens wear. Active anterior segment disorders and evidence of
central microbial keratitis are not allowed. However, evidence of past CLPU will be
allowed so long as no more than 3 such scars are detected bilaterally. Evidence of
more than 3 CLPU-like scars places excessive risk on the participant for subsequent
CIE.

5. The participant must be correctable to 20/25 or better in each eye with spectacles.
Amblyopia will be excluded.

6. Flat and steep corneal curvatures from keratometry readings must be between 39.00 and
48.50 D, respectively. Corneal curvatures outside this range may be indicative of a
disease state, and the participants are not expected to comfortably wear the study
lenses.

7. The participant must own or agree to purchase a pair of spectacles that can be worn
when lenses are removed, during the washout periods, or in case of ocular discomfort
or emergency.

Exclusion Criteria:

1. The participant has worn rigid gas permeable contact lenses within the last 30 days or
PMMA lenses within the past 12 months. These lenses can transiently alter the corneal
shape and influence the fitting of soft contact lenses or alter endothelial cell
morphology.

2. The participant has an immunocompromising disease or any other systemic disease that
in the investigator's opinion will affect ocular health or increase risk during daily
contact lens wear.

3. The participant is taking any medication that in the investigator's opinion will
affect ocular physiology or study participation.

4. The participant has an ocular disease or condition such as aphakia, clinically
significant corneal dystrophies, corneal edema, external ocular infection, iritis, or
had any anterior segment surgery.

5. The participant is taking any ocular medications. If a participant was previous taking
any ocular medications, the medications must have been discontinued at least 2 weeks
prior to enrollment.

6. The participant must have less than or equal to grade 2 on any of the slit lamp
observations of: upper tarsal papilla, corneal staining, corneal neovascularization,
conjunctival injection, and lid erythema or scales.

7. The participant is currently pregnant or lactating. Participant who become pregnant
during the study will be discontinued.

8. An employee or member of the UHCMC Eye Institute or a family member of any study
personnel.