Role of Hyaluronic Acid in Causing Cancer Stem Cell Growth in the Bones of Patients With Breast Cancer
| Status: | Withdrawn |
|---|---|
| Conditions: | Breast Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 20 - 60 |
| Updated: | 7/4/2018 |
| Start Date: | March 2015 |
| End Date: | June 2017 |
Role of Hyaluronic Acid in Cancer Stem Cell Niche
This research trial studies the role of a substance called hyaluronic acid in causing the
growth of cancer stem cells in the bones of patients with breast cancer. Cancer stem cells
are a type of cancer cells that may cause the cancer to spread to other parts of the body.
Studying samples of blood and bone marrow from patients and animal models in the laboratory
may help doctors learn more about whether hyaluronic acid affects the growth of cancer in the
bones.
growth of cancer stem cells in the bones of patients with breast cancer. Cancer stem cells
are a type of cancer cells that may cause the cancer to spread to other parts of the body.
Studying samples of blood and bone marrow from patients and animal models in the laboratory
may help doctors learn more about whether hyaluronic acid affects the growth of cancer in the
bones.
PRIMARY OBJECTIVES:
I. To evaluate the hypothesis that there are more hyaluronan synthase 2 (HAS2)+ cells in
patients with bone metastasis compared to patients with only local disease.
SECONDARY OBJECTIVES:
I. To evaluate the hypothesis that cells with HAS2+ and cancer stem cell (CSC)+ (cluster of
differentiation [CD]24-/CD44+/epithelial specific antigen [ESA]+) cells will have the most
aggressive growth in the bone, using an animal model.
OUTLINE:
Blood and bone marrow samples are collected and analyzed via flow cytometry and polymerase
chain reaction (PCR). Cells are also transplanted into mice and studied.
I. To evaluate the hypothesis that there are more hyaluronan synthase 2 (HAS2)+ cells in
patients with bone metastasis compared to patients with only local disease.
SECONDARY OBJECTIVES:
I. To evaluate the hypothesis that cells with HAS2+ and cancer stem cell (CSC)+ (cluster of
differentiation [CD]24-/CD44+/epithelial specific antigen [ESA]+) cells will have the most
aggressive growth in the bone, using an animal model.
OUTLINE:
Blood and bone marrow samples are collected and analyzed via flow cytometry and polymerase
chain reaction (PCR). Cells are also transplanted into mice and studied.
Inclusion Criteria:
- Patients must have newly diagnosed, histologically confirmed primary and/or metastatic
breast cancer
- Ability to understand and the willingness to sign an Institutional Review Board
(IRB)-approved informed consent document
Exclusion Criteria:
- Patients who have had chemotherapy or radiotherapy
We found this trial at
1
site
1 Medical Center Blvd
Winston-Salem, North Carolina 27157
Winston-Salem, North Carolina 27157
336-716-2011
Wake Forest University Health Sciences Welcome to Wake Forest Baptist Medical Center, a fully integrated...
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