Perceptual Deficits in Schizophrenia
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Schizophrenia, Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - 60 |
| Updated: | 11/9/2017 |
| Start Date: | August 2014 |
| End Date: | December 2018 |
Cognitive Remediation for Perceptual Deficits in Schizophrenia
In this study, participants with schizophrenia and schizoaffective are given computer
exercises to complete. The goals of the study are to determine whether: 1) any of the
computer exercises can improve information processing problems in schizophrenia, 2)
improvements in information processing are related to other cognitive improvements, and 3)
there are changes in brain activity associated with using the computer exercises.
The study will involve clinical interviews, cognitive tests, and frequent computerized
cognitive training over the course of 2 months. Some participants will also have
electroencephalography, a non-invasive test that measures brain activity, to determine
whether there are changes in brain activity with the computer training.
exercises to complete. The goals of the study are to determine whether: 1) any of the
computer exercises can improve information processing problems in schizophrenia, 2)
improvements in information processing are related to other cognitive improvements, and 3)
there are changes in brain activity associated with using the computer exercises.
The study will involve clinical interviews, cognitive tests, and frequent computerized
cognitive training over the course of 2 months. Some participants will also have
electroencephalography, a non-invasive test that measures brain activity, to determine
whether there are changes in brain activity with the computer training.
Schizophrenia is a disabling neurodevelopmental illness, affecting nearly 1% of the
population. The disability of schizophrenia is due in large part to the effects of the
illness on cognitive faculties. Current medications for schizophrenia do not generally
improve cognition, so a major contribution to disability remains undertreated. Computerized
cognitive remediation programs, which produce activity-dependent recruitment of neural
resources to specifically enhance under-functioning brain systems, have been effective at
improving both cognition and community functioning in patients with schizophrenia, but the
effects are still modest. Our preliminary work has suggested that our training is associated
with improvements in visual memory, though visual memory has been a cognitive area more
refractory to cognitive training.
In this study, participants with schizophrenia or schizoaffective disorder will be randomized
to receive different computer exercises to help determine whether computer exercises can
improve memory in schizophrenia, and whether the cognitive training is associated with
changes in neural activity.
population. The disability of schizophrenia is due in large part to the effects of the
illness on cognitive faculties. Current medications for schizophrenia do not generally
improve cognition, so a major contribution to disability remains undertreated. Computerized
cognitive remediation programs, which produce activity-dependent recruitment of neural
resources to specifically enhance under-functioning brain systems, have been effective at
improving both cognition and community functioning in patients with schizophrenia, but the
effects are still modest. Our preliminary work has suggested that our training is associated
with improvements in visual memory, though visual memory has been a cognitive area more
refractory to cognitive training.
In this study, participants with schizophrenia or schizoaffective disorder will be randomized
to receive different computer exercises to help determine whether computer exercises can
improve memory in schizophrenia, and whether the cognitive training is associated with
changes in neural activity.
Inclusion Criteria:
- schizophrenia or schizoaffective disorder
- English speaking and reading
Exclusion Criteria:
- current substance abuse
- visual impairment
- neurological conditions
- current enrollment in another research study
We found this trial at
1
site
333 Cedar St
New Haven, Connecticut 06504
New Haven, Connecticut 06504
(203) 432-4771
Principal Investigator: Toral S Surti, MD, PhD
Phone: 203-974-7538
Yale University School of Medicine Founded in 1810, the Yale School of Medicine is a...
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