Treating Deep Seizure Foci With Noninvasive Surface Brain Stimulation
| Status: | Recruiting |
|---|---|
| Conditions: | Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 18 - 64 |
| Updated: | 2/23/2019 |
| Start Date: | January 2015 |
| End Date: | January 2020 |
| Contact: | Bernard S Chang, MD, MMSc |
| Email: | bchang@bidmc.harvard.edu |
| Phone: | 617-667-2889 |
The overall goal of this study is to open up the promising treatment of repetitive
transcranial magnetic stimulation (rTMS), which has been shown to be effective against
seizures in patients with surface neocortical foci, to a much larger population of patients
with mesial temporal lobe epilepsy (MTLE) and other forms of epilepsy with deep foci, who are
not currently considered good rTMS candidates.
The investigators hypothesize that rTMS can modulate the hyperexcitable state in patients
with deep seizure foci by targeting its usage to accessible cortical partner regions. In this
study the investigators aim 1) to map the functional connectivity of the epileptogenic mesial
temporal lobe in patients with medically refractory mesial temporal lobe epilepsy; and 2) to
perform a randomized controlled assessment of repetitive transcranial magnetic stimulation
protocols applied to specific neocortical targets in mesial temporal lobe epilepsy. The
methods used in this study will include magnetic resonance imaging (MRI) of the brain,
electroencephalography (EEG), and transcranial magnetic stimulation (TMS).
transcranial magnetic stimulation (rTMS), which has been shown to be effective against
seizures in patients with surface neocortical foci, to a much larger population of patients
with mesial temporal lobe epilepsy (MTLE) and other forms of epilepsy with deep foci, who are
not currently considered good rTMS candidates.
The investigators hypothesize that rTMS can modulate the hyperexcitable state in patients
with deep seizure foci by targeting its usage to accessible cortical partner regions. In this
study the investigators aim 1) to map the functional connectivity of the epileptogenic mesial
temporal lobe in patients with medically refractory mesial temporal lobe epilepsy; and 2) to
perform a randomized controlled assessment of repetitive transcranial magnetic stimulation
protocols applied to specific neocortical targets in mesial temporal lobe epilepsy. The
methods used in this study will include magnetic resonance imaging (MRI) of the brain,
electroencephalography (EEG), and transcranial magnetic stimulation (TMS).
Inclusion Criteria:
- Diagnosis of mesial temporal lobe epilepsy based on the combination of clinical
semiology, neuroimaging findings, and electroencephalogram results.
- At least 1 seizure with loss of awareness per 4-week period, on average, despite the
use of antiepileptic drugs
Exclusion Criteria:
- Prior brain surgery or exposure to transcranial magnetic stimulation
- Rapidly progressive brain lesions
- Inability to tolerate MRI or TMS
- Specific MRI or TMS contraindication as set forth in standard protocols of our
institution
We found this trial at
1
site
330 Brookline Ave
Boston, Massachusetts 02215
Boston, Massachusetts 02215
617-667-7000
Phone: 617-667-4088
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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